Title |
Role of metabolism in cancer cell radioresistance and radiosensitization methods
|
---|---|
Published in |
Journal of Experimental & Clinical Cancer Research, April 2018
|
DOI | 10.1186/s13046-018-0758-7 |
Pubmed ID | |
Authors |
Le Tang, Fang Wei, Yingfen Wu, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Hao Deng, Ke Cao, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng |
Abstract |
Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably changes, which may result in the development of resistance to radiation. Here, we discussed the relationships between radioresistance and mitochondrial and glucose metabolic pathways, aiming to elucidate the interplay between the tumor cell metabolism and radiotherapy resistance. In this review, we additionally summarized the potential therapeutic targets in the metabolic pathways. The aim of this review was to provide a theoretical basis and relevant references, which may lead to the improvement of the sensitivity of radiotherapy and prolong the survival of cancer patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 20% |
Italy | 1 | 20% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 269 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 47 | 17% |
Student > Bachelor | 36 | 13% |
Researcher | 29 | 11% |
Student > Master | 29 | 11% |
Student > Doctoral Student | 19 | 7% |
Other | 32 | 12% |
Unknown | 77 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 62 | 23% |
Medicine and Dentistry | 46 | 17% |
Agricultural and Biological Sciences | 17 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 5% |
Immunology and Microbiology | 8 | 3% |
Other | 35 | 13% |
Unknown | 87 | 32% |