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Mendeley readers
Attention Score in Context
| Title |
Voxel-based meta-analysis of grey matter changes in Alzheimer’s disease
|
|---|---|
| Published in |
Translational Neurodegeneration, March 2015
|
| DOI | 10.1186/s40035-015-0027-z |
| Pubmed ID | |
| Authors |
Wen-Ying Wang, Jin-Tai Yu, Yong Liu, Rui-Hua Yin, Hui-Fu Wang, Jun Wang, Lin Tan, Joaquim Radua, Lan Tan |
| Abstract |
Voxel-based morphometry (VBM) using structural brain MRI has been widely used for the assessment of impairment in Alzheimer's disease (AD), but previous studies in VBM studies on AD remain inconsistent. We conducted meta-analyses to integrate the reported studies to determine the consistent grey matter alterations in AD based on VBM method. The PubMed, ISI Web of Science, EMBASE and Medline database were searched for articles between 1995 and June 2014. Manual searches were also conducted, and authors of studies were contacted for additional data. Coordinates were extracted from clusters with significant grey matter difference between AD patients and healthy controls (HC). Meta-analysis was performed using a new improved voxel-based meta-analytic method, Effect Size Signed Differential Mapping (ES-SDM). Thirty data-sets comprising 960 subjects with AD and 1195 HC met inclusion criteria. Grey matter volume (GMV) reduction at 334 coordinates in AD and no GMV increase were found in the current meta-analysis. Significant reductions in GMV were robustly localized in the limbic regions (left parahippocampl gyrus and left posterior cingulate gyrus). In addition, there were GM decreases in right fusiform gyrus and right superior frontal gyrus. The findings remain largely unchanged in the jackknife sensitivity analyses. Our meta-analysis clearly identified GMV atrophy in AD. These findings confirm that the most prominent and replicable structural abnormalities in AD are in the limbic regions and contributes to the understanding of pathophysiology underlying AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 126 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 15% |
| Student > Ph. D. Student | 16 | 13% |
| Researcher | 14 | 11% |
| Student > Doctoral Student | 10 | 8% |
| Student > Bachelor | 9 | 7% |
| Other | 23 | 18% |
| Unknown | 37 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 19% |
| Psychology | 22 | 17% |
| Neuroscience | 20 | 16% |
| Engineering | 6 | 5% |
| Computer Science | 4 | 3% |
| Other | 10 | 8% |
| Unknown | 42 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2023.
All research outputs
#2,485,392
of 25,373,627 outputs
Outputs from Translational Neurodegeneration
#92
of 384 outputs
Outputs of similar age
#31,147
of 277,996 outputs
Outputs of similar age from Translational Neurodegeneration
#2
of 5 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 384 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,996 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.