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Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease

Overview of attention for article published in Alzheimer's Research & Therapy, June 2011
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Title
Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease
Published in
Alzheimer's Research & Therapy, June 2011
DOI 10.1186/alzrt83
Pubmed ID
Authors

Jake G Hoekstra, Kathleen S Montine, Jing Zhang, Thomas J Montine

Abstract

In neurons, mitochondria serve a wide variety of processes that are integral to their function and survival. It is, therefore, not surprising that evidence of mitochondrial dysfunction is observed across numerous neurodegenerative diseases. Alzheimer's disease and Parkinson's disease are two such diseases in which aberrant mitochondrial activity is proposed to contribute to pathogenesis. Current therapies for each disease target various mechanisms, but few, if any, directly target improved mitochondrial function. Recent discoveries pertaining to mitochondrial dynamics reveal that regulation of mitochondrial fission and fusion may play a key role in the pathogenesis of these diseases and consequently could be novel future therapeutic targets.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 8%
Unknown 22 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 25%
Student > Ph. D. Student 5 21%
Student > Bachelor 3 13%
Other 2 8%
Student > Master 2 8%
Other 4 17%
Unknown 2 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 29%
Medicine and Dentistry 6 25%
Biochemistry, Genetics and Molecular Biology 6 25%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Unknown 3 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2011.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Alzheimer's Research & Therapy
#1,435
of 1,464 outputs
Outputs of similar age
#117,893
of 127,115 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#3
of 3 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,464 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,115 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.