Title |
Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications
|
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Published in |
BMC Medicine, April 2015
|
DOI | 10.1186/s12916-015-0306-7 |
Pubmed ID | |
Authors |
Mathilde Versini, Pierre-Yves Jeandel, Tomer Bashi, Giorgia Bizzaro, Miri Blank, Yehuda Shoenfeld |
Abstract |
The Hygiene Hypothesis (HH) attributes the dramatic increase in autoimmune and allergic diseases observed in recent decades in Western countries to the reduced exposure to diverse immunoregulatory infectious agents. This theory has since largely been supported by strong epidemiological and experimental evidence. The analysis of these data along with the evolution of the Western world's microbiome enable us to obtain greater insight into microorganisms involved in the HH, as well as their regulatory mechanisms on the immune system. Helminthes and their derivatives were shown to have a protective role. Helminthes' broad immunomodulatory properties have already begun to be exploited in clinical trials of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and type-1 diabetes. In this review, we will dissect the microbial actors thought to be involved in the HH as well as their immunomodulatory mechanisms as emphasized by experimental studies, with a particular attention on parasites. Thereafter, we will review the early clinical trials using helminthes' derivatives focusing on autoimmune diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 4 | 15% |
Australia | 2 | 8% |
United Kingdom | 2 | 8% |
Netherlands | 2 | 8% |
Ecuador | 1 | 4% |
India | 1 | 4% |
France | 1 | 4% |
Unknown | 13 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 18 | 69% |
Scientists | 5 | 19% |
Practitioners (doctors, other healthcare professionals) | 3 | 12% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Indonesia | 1 | <1% |
Kenya | 1 | <1% |
Sweden | 1 | <1% |
Germany | 1 | <1% |
Belgium | 1 | <1% |
India | 1 | <1% |
Nigeria | 1 | <1% |
Poland | 1 | <1% |
Other | 0 | 0% |
Unknown | 273 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 54 | 19% |
Student > Master | 44 | 16% |
Student > Ph. D. Student | 36 | 13% |
Researcher | 27 | 10% |
Other | 18 | 6% |
Other | 39 | 14% |
Unknown | 65 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 59 | 21% |
Agricultural and Biological Sciences | 56 | 20% |
Immunology and Microbiology | 30 | 11% |
Biochemistry, Genetics and Molecular Biology | 24 | 8% |
Veterinary Science and Veterinary Medicine | 6 | 2% |
Other | 33 | 12% |
Unknown | 75 | 27% |