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A pilot study of change in fracture risk in patients with acute respiratory distress syndrome

Overview of attention for article published in Critical Care, December 2015
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  • Good Attention Score compared to outputs of the same age (75th percentile)

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9 X users

Citations

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Title
A pilot study of change in fracture risk in patients with acute respiratory distress syndrome
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-0892-y
Pubmed ID
Authors

Jaikitry Rawal, Mark JW McPhail, Gamumu Ratnayake, Pearl Chan, John Moxham, Stephen DR Harridge, Nicholas Hart, Hugh E Montgomery, Zudin A Puthucheary

Abstract

Acute skeletal muscle wasting is a major contributor to post critical illness physical impairment. However, the bone response remains uncharacterized. We prospectively investigated the early changes in bone mineral density (BMD) and fracture risk in critical illness. Patients were prospectively recruited ≤ 24 hours following intensive care unit (ICU) admission to a University Teaching and a Community Hospital (August 2009 to April 2011).All were aged >18 years and expected to be intubated for >48 hours, spend >7 days in critical care and survive ICU admission. Forty-six patients were studied (55.3% male) with an age of 54.4 years (95% Confidence Interval (CI) 49.1-59.6)years and APACHE II score 23.9 (95%CI 22.4-25.5).Calcaneal Dual X-ray Absorptiometry (DXA) assessment of BMD was performed on day 1 and 10. Increase in fracture risk was calculated from the change in T-score. BMD did not change between day 1 and 10 in the cohort overall (0.434 (95%CI 0.405-0.463) vs. 0.425 g/cm(2) (95%CI 0.399-0.450), p = 0.58).Multivariable logistical regression revealed admission corrected calcium (OR 1.980 (95%CI 1.089-3.609), p = 0.026) and admission PaO2 to FiO2 ratio (OR 0.916 (95%CI 0.833-0.998), p = 0.044)to be associated with >2% loss of BMD. Patients with Acute Respiratory Distress Syndrome had a greater loss in BMD than those without (-2.81 (95%CI -5.73-0.118)%, n = 34 vs. 2.40 (95%CI 0.204-4.586)%,n = 12, p = 0.029). In the 34 patients with Acute Respiratory Distress Syndrome, fracture risk increased by 19.4% (95%CI 13.9-25.0%). Patients with acute respiratory distress syndrome demonstrated early and rapid bone demineralisation with associated increase in fracture risk.

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X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Other 5 15%
Student > Ph. D. Student 5 15%
Student > Bachelor 4 12%
Student > Postgraduate 3 9%
Student > Master 3 9%
Other 9 27%
Unknown 4 12%
Readers by discipline Count As %
Medicine and Dentistry 19 58%
Nursing and Health Professions 3 9%
Sports and Recreations 1 3%
Arts and Humanities 1 3%
Social Sciences 1 3%
Other 1 3%
Unknown 7 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2019.
All research outputs
#6,875,065
of 25,373,627 outputs
Outputs from Critical Care
#3,844
of 6,554 outputs
Outputs of similar age
#97,692
of 395,397 outputs
Outputs of similar age from Critical Care
#328
of 466 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.