Title |
Use of 4-factor prothrombin complex concentrate in the treatment of a gastrointestinal hemorrhage complicated by dabigatran
|
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Published in |
International Journal of Emergency Medicine, April 2015
|
DOI | 10.1186/s12245-015-0059-2 |
Pubmed ID | |
Authors |
Terrance R McGovern, Justin J McNamee, Christopher Malabanan, Mohamed A Fouad, Nilesh Patel |
Abstract |
Target-specific oral anticoagulants (TSOACs) provide patients and healthcare providers with an alternative to vitamin K antagonists (VKA). The TSOACs are of similar or superior efficacy to warfarin, but unlike VKAs, there are no approved 'antidotes' for rapid reversal of life-threatening bleeding on therapy. We report here the case of an 83-year-old gentleman, who presented to the emergency department with severe gastrointestinal hemorrhage and coagulopathy (hemoglobin: 5.3 g/dL and INR: 2.2) while on the direct thrombin inhibitor dabigatran. His coagulopathy reversed rapidly after administration of 4-factor prothrombin complex concentrate (4 F-PCC), and after initial administration of 2 units of packed red blood cells, no further product transfusions were required. He was discharged 4 days later without further complications. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Puerto Rico | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 19% |
Lecturer | 2 | 13% |
Other | 2 | 13% |
Researcher | 2 | 13% |
Student > Doctoral Student | 1 | 6% |
Other | 4 | 25% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 63% |
Nursing and Health Professions | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Social Sciences | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 0 | 0% |
Unknown | 2 | 13% |