Title |
Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies
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Published in |
Microbiome, April 2018
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DOI | 10.1186/s40168-018-0462-z |
Pubmed ID | |
Authors |
Charlotte De Rudder, Marta Calatayud Arroyo, Sarah Lebeer, Tom Van de Wiele |
Abstract |
Chronic rhinosinusitis (CRS) is a chronic inflammation of the mucosa of the nose and paranasal sinuses affecting approximately 11% of the adult population in Europe. Inadequate immune responses, as well as a dysbiosis of the sinonasal microbiota, have been put forward as aetiological factors of the disease. However, despite the prevalence of this disease, there is no consensus on the aetiology and mechanisms of pathogenesis of CRS. Further research requires in vitro models mimicking the healthy and diseased host environment along with the sinonasal microbiota. This review aims to provide an overview of CRS model systems and proposes in vitro modelling strategies to conduct mechanistic research in an ecological framework on the sinonasal microbiota and its interactions with the host in health and CRS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 14% |
United States | 1 | 14% |
Ireland | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 59 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 25% |
Student > Master | 7 | 12% |
Researcher | 7 | 12% |
Professor > Associate Professor | 4 | 7% |
Student > Bachelor | 3 | 5% |
Other | 3 | 5% |
Unknown | 20 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 10 | 17% |
Agricultural and Biological Sciences | 8 | 14% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Medicine and Dentistry | 6 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 6 | 10% |
Unknown | 21 | 36% |