Title |
The role of death-associated protein 3 in apoptosis, anoikis and human cancer
|
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Published in |
Cancer Cell International, April 2015
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DOI | 10.1186/s12935-015-0187-z |
Pubmed ID | |
Authors |
Umar Wazir, Mona MAW Orakzai, Zubair S Khanzada, Wen G Jiang, Anup K Sharma, Abdul Kasem, Kefah Mokbel |
Abstract |
Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Student > Bachelor | 7 | 21% |
Student > Master | 5 | 15% |
Student > Postgraduate | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 4 | 12% |
Unknown | 4 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 33% |
Agricultural and Biological Sciences | 8 | 24% |
Medicine and Dentistry | 3 | 9% |
Veterinary Science and Veterinary Medicine | 2 | 6% |
Chemistry | 2 | 6% |
Other | 4 | 12% |
Unknown | 3 | 9% |