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Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review

Overview of attention for article published in World Journal of Surgical Oncology, March 2015
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Title
Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review
Published in
World Journal of Surgical Oncology, March 2015
DOI 10.1186/s12957-015-0538-1
Pubmed ID
Authors

Chun-Lan He, Ping Chen, Bing-Lan Xia, Qin Xiao, Feng-Lin Cai

Abstract

Cases of primary gastric adenocarcinoma with metastasis to the breast are extremely rare. Till now, only 38 cases have been reported in PubMed since 1908. We herein reported a race case of gastric adenocarcinoma with metastasis to the right breast. Breast biopsy showed invasive signet-ring cell breast carcinoma in the right breast. She was given a TEC regimen (docetaxel 75 mg/m(2), epirubicin 75 mg/m(2), and cyclophosphamide 600 mg/m(2) every 3 weeks) for one cycle but showed no objective response. Upper gastrointestinal endoscopy demonstrated an ulcerative mass in the gastric body. Biopsy demonstrated low-grade gastric adenocarcinoma with signet-ring features. In immunohistochemistry, mammary malignant cells were positive for cytokeratin 7, cytokeratin 20, villin, and ErbB2/HER2, but negative for gross cystic disease fluid protein-15, estrogen receptor, and progesterone receptor. The diagnosis of metastatic poorly differentiated signet-ring cell adenocarcinoma of the right breast identical to gastric primary was confirmed finally. Gastric cancer with metastasis to the breast can be diagnosed by clinical history, histological findings, and immunohistochemical markers.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 22%
Student > Bachelor 4 17%
Student > Postgraduate 3 13%
Student > Ph. D. Student 1 4%
Lecturer > Senior Lecturer 1 4%
Other 2 9%
Unknown 7 30%
Readers by discipline Count As %
Medicine and Dentistry 11 48%
Nursing and Health Professions 1 4%
Immunology and Microbiology 1 4%
Agricultural and Biological Sciences 1 4%
Neuroscience 1 4%
Other 1 4%
Unknown 7 30%