You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effects of nitric oxide-related compounds in the acute ketamine animal model of schizophrenia
|
|---|---|
| Published in |
BMC Neuroscience, March 2015
|
| DOI | 10.1186/s12868-015-0149-3 |
| Pubmed ID | |
| Authors |
Ludmyla Kandratavicius, Priscila Alves Balista, Daniele Cristina Wolf, Joao Abrao, Paulo Roberto Evora, Alfredo Jose Rodrigues, Cristiano Chaves, Joao Paulo Maia-de-Oliveira, Joao Pereira Leite, Serdar Murat Dursun, Glen Bryan Baker, Francisco Silveira Guimaraes, Jaime Eduardo Cecilio Hallak |
| Abstract |
Better treatments for schizophrenia are urgently needed. The therapeutic use of the nitric oxide (NO)-donor sodium nitroprusside (SNP) in patients with schizophrenia has shown promising results. The role of NO in schizophrenia is still unclear, and NO modulation is unexplored in ketamine (KET) animal models to date. In the present study, we compared the behavioral effects of pre- and post-treatment with SNP, glyceryl trinitrate (GTN), and methylene blue (MB) in the acute KET animal model of schizophrenia. The present study was designed to test whether acute SNP, GTN, and MB treatment taken after (therapeutic effect) or before (preventive effect) a single KET injection would influence the behavior of rats in the sucrose preference test, object recognition task and open field. The results showed that KET induced cognitive deficits and hyperlocomotion. Long- term memory improvement was seen with the therapeutic GTN and SNP treatment, but not with the preventive one. MB pretreatment resulted in long-term memory recovery. GTN pre-, but not post-treatment, tended to increase vertical and horizontal activity in the KET model. Therapeutic and preventive SNP treatment consistently decreased KET-induced hyperlocomotion. NO donors - especially SNP - are promising new pharmacological candidates in the treatment of schizophrenia. In addition, we showed that the potential impact of NO-related compounds on KET-induced behavioral changes may depend on the temporal window of drug administration. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Unknown | 98 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 17% |
| Student > Master | 12 | 12% |
| Student > Doctoral Student | 10 | 10% |
| Student > Bachelor | 10 | 10% |
| Researcher | 7 | 7% |
| Other | 14 | 14% |
| Unknown | 29 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 17% |
| Neuroscience | 17 | 17% |
| Psychology | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 9 | 9% |
| Unknown | 34 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2019.
All research outputs
#6,952,277
of 22,800,560 outputs
Outputs from BMC Neuroscience
#337
of 1,244 outputs
Outputs of similar age
#80,010
of 258,815 outputs
Outputs of similar age from BMC Neuroscience
#4
of 18 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,244 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,815 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.