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Novel pantothenate derivatives for anti-malarial chemotherapy

Overview of attention for article published in Malaria Journal, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
33 Mendeley
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Title
Novel pantothenate derivatives for anti-malarial chemotherapy
Published in
Malaria Journal, April 2015
DOI 10.1186/s12936-015-0673-8
Pubmed ID
Authors

Helmi E Pett, Patrick AM Jansen, Pedro HH Hermkens, Peter NM Botman, Christien A Beuckens-Schortinghuis, Richard H Blaauw, Wouter Graumans, Marga van de Vegte-Bolmer, Karin MJ Koolen, Floris PJT Rutjes, Koen J Dechering, Robert W Sauerwein, Joost Schalkwijk

Abstract

A number of synthetic pantothenate derivatives, such as pantothenamides, are known to inhibit the growth of the human malaria parasite Plasmodium falciparum, by interfering with the parasite Coenzyme A (CoA) biosynthetic pathway. The clinical use of pantothenamides is limited by their sensitivity to breakdown by ubiquitous human pantetheinases of the vanin family. A number of pantothenate derivatives (pantothenones) with potent and specific inhibitory activity against mammalian vanins were tested in a proliferation assay of asexual P. falciparum blood stages alone, and in combination with pantothenamides. The vanin inhibitors were found to protect pantothenamides against breakdown by plasma vanins, thereby preserving the in vitro anti-malarial activity. Moreover, some of the vanin inhibitors showed in vitro anti-malarial activity in the low micromolar range. The most potent antimalarial in this series of compounds (RR8), was found to compete with pantothenate in a combination proliferation assay. No correlation, however, was found between anti-vanin and anti-malarial activity, nor was pantetheinase activity detected in P. falciparum extracts. Growth inhibition is most likely due to competition with pantothenate, rather than pantetheinase inhibition. As vanin inhibitors of the pantothenone class are stable in biological fluids and are non-toxic to mammalian cells, they may represent novel pantothenate-based anti-malarials, either on their own or in combination with pantothenamides.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Student > Bachelor 5 15%
Researcher 3 9%
Student > Master 3 9%
Student > Doctoral Student 2 6%
Other 8 24%
Unknown 4 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 30%
Agricultural and Biological Sciences 9 27%
Medicine and Dentistry 4 12%
Chemistry 2 6%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 6 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2017.
All research outputs
#1,633,508
of 11,648,047 outputs
Outputs from Malaria Journal
#472
of 3,432 outputs
Outputs of similar age
#39,699
of 214,570 outputs
Outputs of similar age from Malaria Journal
#21
of 107 outputs
Altmetric has tracked 11,648,047 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,432 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,570 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.