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Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity

Overview of attention for article published in BMC Neuroscience, April 2015
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  • Good Attention Score compared to outputs of the same age (73rd percentile)

Mentioned by

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9 tweeters

Citations

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15 Dimensions

Readers on

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25 Mendeley
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Title
Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity
Published in
BMC Neuroscience, April 2015
DOI 10.1186/s12868-015-0158-2
Pubmed ID
Authors

John S Del Rosario, Katherine Genevieve Feldmann, Towfiq Ahmed, Uzair Amjad, BakKeung Ko, JunHyung An, Tauhid Mahmud, Maha Salama, Shirley Mei, Daniel Asemota, Itzhak Mano

Abstract

Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases. Many mechanisms have been suggested to mediate excitotoxicity, but their significance across diverse excitotoxic scenarios remains unclear. Death Associated Protein Kinase (DAPK), a critical molecular switch that controls a range of key signaling and cell death pathways, has been suggested to have an important role in excitotoxicity. However, the molecular mechanism by which DAPK exerts its effect is controversial. A few distinct mechanisms have been suggested by single (sometimes contradicting) studies, and a larger array of potential mechanisms is implicated by the extensive interactome of DAPK. Here we analyze a well-characterized model of excitotoxicity in the nematode C. elegans to show that DAPK is an important mediator of excitotoxic neurodegeneration across a large evolutionary distance. We further show that some proposed mechanisms of DAPK's action (modulation of synaptic strength, involvement of the DANGER-related protein MAB-21, and autophagy) do not have a major role in nematode excitotoxicity. In contrast, Pin1/PINN-1 (a DAPK interaction-partner and a peptidyl-prolyl isomerase involved in chronic neurodegenerative conditions) suppresses neurodegeneration in our excitotoxicity model. Our studies highlight the prominence of DAPK and Pin1/PINN-1 as conserved mediators of cell death processes in diverse scenarios of neurodegeneration.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 20%
Student > Ph. D. Student 5 20%
Student > Master 3 12%
Student > Doctoral Student 3 12%
Professor > Associate Professor 2 8%
Other 3 12%
Unknown 4 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 16%
Medicine and Dentistry 4 16%
Biochemistry, Genetics and Molecular Biology 3 12%
Nursing and Health Professions 3 12%
Pharmacology, Toxicology and Pharmaceutical Science 3 12%
Other 5 20%
Unknown 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2021.
All research outputs
#5,242,344
of 20,423,840 outputs
Outputs from BMC Neuroscience
#249
of 1,189 outputs
Outputs of similar age
#61,845
of 241,939 outputs
Outputs of similar age from BMC Neuroscience
#1
of 1 outputs
Altmetric has tracked 20,423,840 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,189 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,939 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them