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Mendeley readers
Attention Score in Context
| Title |
Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease
|
|---|---|
| Published in |
Molecular Neurodegeneration, March 2015
|
| DOI | 10.1186/s13024-015-0007-x |
| Pubmed ID | |
| Authors |
Hyundong Song, Minho Moon, Han Kyoung Choe, Dong-Hee Han, Changhwan Jang, Ahbin Kim, Sehyung Cho, Kyungjin Kim, Inhee Mook-Jung |
| Abstract |
Patients with Alzheimer's disease (AD) frequently experience disruption of their circadian rhythms, but whether and how circadian clock molecules are perturbed by AD remains unknown. AD is an age-related neurological disorder and amyloid-β (Aβ) is one of major causative molecules in the pathogenesis of AD. In this study, we investigated the role of Aβ in the regulation of clock molecules and circadian rhythm using an AD mouse model. These mice exhibited altered circadian behavior, and altered expression patterns of the circadian clock genes, Bmal1 and Per2. Using cultured cells, we showed that Aβ induces post-translational degradation of the circadian clock regulator CBP, as well as the transcription factor BMAL1, which forms a complex with the master circadian transcription factor CLOCK. Aβ-induced degradation of BMAL1 and CBP correlated with the reduced binding of transcription factors to the Per2 promoter, which in turn resulted in disruptions to PER2 protein expression and the oscillation of Per2 mRNA levels. Our results elucidate the underlying mechanisms for disrupted circadian rhythm in AD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 159 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 18% |
| Student > Ph. D. Student | 26 | 16% |
| Researcher | 15 | 9% |
| Student > Master | 15 | 9% |
| Professor > Associate Professor | 10 | 6% |
| Other | 23 | 14% |
| Unknown | 43 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 30 | 19% |
| Agricultural and Biological Sciences | 23 | 14% |
| Biochemistry, Genetics and Molecular Biology | 22 | 14% |
| Medicine and Dentistry | 19 | 12% |
| Psychology | 7 | 4% |
| Other | 13 | 8% |
| Unknown | 47 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2017.
All research outputs
#2,210,442
of 22,800,560 outputs
Outputs from Molecular Neurodegeneration
#249
of 847 outputs
Outputs of similar age
#30,401
of 263,725 outputs
Outputs of similar age from Molecular Neurodegeneration
#6
of 16 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 847 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.2. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,725 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.