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RETRACTED ARTICLE: Anti-inflammatory and protective investigations on the effects of Theranekron® ”an alcoholic extract of the Tarantula cubensis” on wound healing of peritoneal in the rat: an in…

Overview of attention for article published in Diagnostic Pathology, April 2015
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Title
RETRACTED ARTICLE: Anti-inflammatory and protective investigations on the effects of Theranekron® ”an alcoholic extract of the Tarantula cubensis” on wound healing of peritoneal in the rat: an in vivo comparative study
Published in
Diagnostic Pathology, April 2015
DOI 10.1186/s13000-015-0252-x
Pubmed ID
Authors

Farajollah Adib-Hashemi, Farshad Farahmand, Shamim Fattah Hesari, Bijan Rezakhaniha, Ehsan Fallah, Amir Farshid Fayyaz, Masoomeh Dadpay

Abstract

The present study sought to investigate the effects of Tarantula cubensis extract (TC; Theranekron®) on the histopathological scores of peritoneal wound healing after laparotomy in the rats. This study was designed to investigate the effects of Theranekron on the peritoneal wound healing after wound creation, on days9, 14, 19, 24 and 29 post-injury in rats. Twenty-four mature Wister-albino male rats were randomly divided into two groups. In the experimental group, TC was repeatedly injected subcutaneously (SC) over the lesion 9, 14,19 and 24 days after laparotomy, whereas the control group received only normal saline by subcutaneous injection and then the animal groups were euthanized9, 14, 19, 24, and 29 days after wounding respectively by intravenous injections of pentobarbital (50 mg/kg). Finally, assessment of the peritoneal wound healing between the groups was carried out by histopathologic data and statistical tests as Mann-Whitney U, Wilcoxon W and Z RESULTS: Histopathological examination indicated significant improvement in angiogenesis, re-epithelialization and less inflammatory response in comparison to control and also, revealed matured, compact and parallel deposition of collagen fibrils on day 29. So, at long term, treatment reduced the inflammation and increased the quality and rate of wound re- epithelialization compared to controls(P < 0.05). Furthermore, excluding the control group, rats exhibited the most pronounced effect on wound closure, with the statistically significant improvement in wound healing being seen at post-operative day 29. Moreover, collagen content on days 24 and 29 in the test group was found to be higher than in the healthy group. To warp up, treated groups had a significant increase in peritoneal wound healing area compared to the control group on all days (P < 0.05). Our results suggested that Theranekron have delivered a novel therapeutic route for wound treatment in clinical practice. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2958770714954315 .

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 15%
Student > Ph. D. Student 4 15%
Researcher 4 15%
Professor > Associate Professor 4 15%
Student > Master 3 11%
Other 3 11%
Unknown 5 19%
Readers by discipline Count As %
Medicine and Dentistry 5 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Veterinary Science and Veterinary Medicine 1 4%
Nursing and Health Professions 1 4%
Agricultural and Biological Sciences 1 4%
Other 6 22%
Unknown 11 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2015.
All research outputs
#15,859,404
of 24,167,226 outputs
Outputs from Diagnostic Pathology
#515
of 1,156 outputs
Outputs of similar age
#152,897
of 267,816 outputs
Outputs of similar age from Diagnostic Pathology
#31
of 49 outputs
Altmetric has tracked 24,167,226 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,156 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,816 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.