You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Modulation of angiotensin II signaling in the prevention of fibrosis
|
|---|---|
| Published in |
Fibrogenesis & Tissue Repair, April 2015
|
| DOI | 10.1186/s13069-015-0023-z |
| Pubmed ID | |
| Authors |
Amanda M Murphy, Alison L Wong, Michael Bezuhly |
| Abstract |
Over the last decade, it has become clear that the role of angiotensin II extends far beyond recognized renal and cardiovascular effects. The presence of an autologous renin-angiotensin system has been demonstrated in almost all tissues of the body. It is now known that angiotensin II acts both independently and in synergy with TGF-beta to induce fibrosis via the angiotensin type 1 receptor (AT1) in a multitude of tissues outside of the cardiovascular and renal systems, including pulmonary fibrosis, intra-abdominal fibrosis, and systemic sclerosis. Interestingly, recent studies have described a paradoxically regenerative effect of the angiotensin system via stimulation of the angiotensin type 2 receptor (AT2). Activation of AT2 has been shown to ameliorate fibrosis in animal models of skeletal muscle, gastrointestinal, and neurologic diseases. Clinical reports suggest a beneficial role for modulation of angiotensin II signaling in cutaneous scarring. This article reviews current knowledge on the role that angiotensin II plays in tissue fibrosis, as well as current and potential therapies targeting this system. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | 17% |
| Japan | 1 | 17% |
| Kuwait | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Thailand | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 168 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 15% |
| Student > Ph. D. Student | 24 | 14% |
| Researcher | 22 | 13% |
| Student > Master | 15 | 9% |
| Student > Doctoral Student | 11 | 6% |
| Other | 26 | 15% |
| Unknown | 47 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 26% |
| Biochemistry, Genetics and Molecular Biology | 28 | 16% |
| Agricultural and Biological Sciences | 18 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Engineering | 4 | 2% |
| Other | 18 | 11% |
| Unknown | 50 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2022.
All research outputs
#4,651,676
of 25,223,158 outputs
Outputs from Fibrogenesis & Tissue Repair
#18
of 86 outputs
Outputs of similar age
#54,198
of 271,786 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#1
of 5 outputs
Altmetric has tracked 25,223,158 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 86 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,786 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them