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An experimental study of muscular injury repair in a mouse model of notexin-induced lesion with EPI® technique

Overview of attention for article published in BMC Sports Science, Medicine and Rehabilitation, April 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#33 of 389)
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

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47 tweeters
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5 Facebook pages

Citations

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20 Dimensions

Readers on

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111 Mendeley
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Title
An experimental study of muscular injury repair in a mouse model of notexin-induced lesion with EPI® technique
Published in
BMC Sports Science, Medicine and Rehabilitation, April 2015
DOI 10.1186/s13102-015-0002-0
Pubmed ID
Authors

Ferran Abat, Soraya-L Valles, Pablo-Eduardo Gelber, Fernando Polidori, Adrian Jorda, Sergio García-Herreros, Joan-Carles Monllau, Jose-Manuel Sanchez-Ibáñez

Abstract

The mechanisms of muscle injury repair after EPI® technique, a treatment based on electrical stimulation, have not been described. This study determines whether EPI® therapy could improve muscle damage. Twenty-four rats were divided into a control group, Notexin group (7 and 14 days) and a Notexin + EPI group. To induce muscle injury, Notexin was injected in the quadriceps of the left extremity of rats. Pro-inflammatory interleukin 1-beta (IL-1beta) and tumoral necrosis factor-alpha (TNF-alpha) were determined by ELISA. The expression of receptor peroxisome gamma proliferator activator (PPAR-gamma), vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-1 (VEGF-R1) were determined by western-blot. The plasma levels of TNF-alpha and IL-1beta in Notexin-injured rats showed a significant increase compared with the control group. EPI® produced a return of TNF-alpha and IL-1beta values to control levels. PPAR-gamma expression diminished injured quadriceps muscle in rats. EPI® increased PPAR-gamma, VEGF and VEGF-R1 expressions. EPI® decreased plasma levels of pro-inflammatory TNF-alpha and IL-1beta and increased anti-inflammatory PPAR-gamma and proangiogenic factors as well as VEGF and VEGF-R1 expressions. The EPI® technique may affect inflammatory mediators in damaged muscle tissue and influences the new vascularization of the injured area. These results suggest that EPI® might represent a useful new therapy for the treatment of muscle injuries. Although our study in rats may represent a valid approach to evaluate EPI® treatment, studies designed to determine how the EPI® treatment may affect recovery of injury in humans are needed.

Twitter Demographics

The data shown below were collected from the profiles of 47 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 4 4%
Unknown 107 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 21 19%
Student > Ph. D. Student 14 13%
Student > Master 11 10%
Professor > Associate Professor 8 7%
Researcher 7 6%
Other 27 24%
Unknown 23 21%
Readers by discipline Count As %
Medicine and Dentistry 41 37%
Nursing and Health Professions 15 14%
Agricultural and Biological Sciences 8 7%
Sports and Recreations 7 6%
Unspecified 2 2%
Other 7 6%
Unknown 31 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 38. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2019.
All research outputs
#800,219
of 20,573,048 outputs
Outputs from BMC Sports Science, Medicine and Rehabilitation
#33
of 389 outputs
Outputs of similar age
#11,649
of 242,654 outputs
Outputs of similar age from BMC Sports Science, Medicine and Rehabilitation
#1
of 1 outputs
Altmetric has tracked 20,573,048 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 389 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,654 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them