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X Demographics
Mendeley readers
Attention Score in Context
| Title |
An experimental study of muscular injury repair in a mouse model of notexin-induced lesion with EPI® technique
|
|---|---|
| Published in |
BMC Sports Science, Medicine and Rehabilitation, April 2015
|
| DOI | 10.1186/s13102-015-0002-0 |
| Pubmed ID | |
| Authors |
Ferran Abat, Soraya-L Valles, Pablo-Eduardo Gelber, Fernando Polidori, Adrian Jorda, Sergio García-Herreros, Joan-Carles Monllau, Jose-Manuel Sanchez-Ibáñez |
| Abstract |
The mechanisms of muscle injury repair after EPI® technique, a treatment based on electrical stimulation, have not been described. This study determines whether EPI® therapy could improve muscle damage. Twenty-four rats were divided into a control group, Notexin group (7 and 14 days) and a Notexin + EPI group. To induce muscle injury, Notexin was injected in the quadriceps of the left extremity of rats. Pro-inflammatory interleukin 1-beta (IL-1beta) and tumoral necrosis factor-alpha (TNF-alpha) were determined by ELISA. The expression of receptor peroxisome gamma proliferator activator (PPAR-gamma), vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-1 (VEGF-R1) were determined by western-blot. The plasma levels of TNF-alpha and IL-1beta in Notexin-injured rats showed a significant increase compared with the control group. EPI® produced a return of TNF-alpha and IL-1beta values to control levels. PPAR-gamma expression diminished injured quadriceps muscle in rats. EPI® increased PPAR-gamma, VEGF and VEGF-R1 expressions. EPI® decreased plasma levels of pro-inflammatory TNF-alpha and IL-1beta and increased anti-inflammatory PPAR-gamma and proangiogenic factors as well as VEGF and VEGF-R1 expressions. The EPI® technique may affect inflammatory mediators in damaged muscle tissue and influences the new vascularization of the injured area. These results suggest that EPI® might represent a useful new therapy for the treatment of muscle injuries. Although our study in rats may represent a valid approach to evaluate EPI® treatment, studies designed to determine how the EPI® treatment may affect recovery of injury in humans are needed. |
X Demographics
The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 22 | 48% |
| Venezuela, Bolivarian Republic of | 2 | 4% |
| Colombia | 1 | 2% |
| Grenada | 1 | 2% |
| Paraguay | 1 | 2% |
| United States | 1 | 2% |
| Chile | 1 | 2% |
| Brazil | 1 | 2% |
| Dominican Republic | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 15 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 87% |
| Practitioners (doctors, other healthcare professionals) | 4 | 9% |
| Scientists | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 3% |
| Unknown | 129 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 19% |
| Student > Ph. D. Student | 14 | 11% |
| Student > Master | 13 | 10% |
| Researcher | 9 | 7% |
| Other | 8 | 6% |
| Other | 30 | 23% |
| Unknown | 34 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 32% |
| Nursing and Health Professions | 21 | 16% |
| Sports and Recreations | 9 | 7% |
| Agricultural and Biological Sciences | 7 | 5% |
| Unspecified | 4 | 3% |
| Other | 9 | 7% |
| Unknown | 40 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2019.
All research outputs
#1,022,665
of 24,068,839 outputs
Outputs from BMC Sports Science, Medicine and Rehabilitation
#43
of 538 outputs
Outputs of similar age
#13,179
of 268,653 outputs
Outputs of similar age from BMC Sports Science, Medicine and Rehabilitation
#3
of 5 outputs
Altmetric has tracked 24,068,839 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,653 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.