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Diffusion tensor MR imaging characteristics of cerebral white matter development in fetal pigs

Overview of attention for article published in BMC Medical Imaging, August 2017
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Title
Diffusion tensor MR imaging characteristics of cerebral white matter development in fetal pigs
Published in
BMC Medical Imaging, August 2017
DOI 10.1186/s12880-017-0205-9
Pubmed ID
Authors

Wenxu Qi, Song Gao, Caixia Liu, Gongyu Lan, Xue Yang, Qiyong Guo

Abstract

The purpose of this study was to investigate the anisotropic features of fetal pig cerebral white matter (WM) development by magnetic resonance diffusion tensor imaging, and to evaluate the developmental status of cerebral WM in different anatomical sites at different times. Fetal pigs were divided into three groups according to gestational age: E69 (n = 8), E85 (n = 11), and E114 (n = 6). All pigs were subjected to conventional magnetic resonance imaging (MRI) and diffusion tensor imaging using a GE Signa 3.0 T MRI system (GE Healthcare, Sunnyvale, CA, USA). Fractional anisotropy (FA) was measured in deep WM structures and peripheral WM regions. After the MRI scans,the animals were sacrificed and pathology sections were prepared for hematoxylin & eosin (HE) staining and luxol fast blue (LFB) staining. Data were statistically analyzed with SPSS version 16.0 (SPSS, Chicago, IL, USA). A P-value < 0.05 was considered statistically significant. Mean FA values for each subject region of interest (ROI), and deep and peripheral WM at different gestational ages were calculated, respectively, and were plotted against gestational age with linear correlation statistical analyses. The differences of data were analyzed with univariate ANOVA analyses. There were no significant differences in FAs between the right and left hemispheres. Differences were observed between peripheral WM and deep WM in fetal brains. A significant FA growth with increased gestational age was found when comparing E85 group and E114 group. There was no difference in the FA value of deep WM between the E69 group and E85 group. The HE staining and LFB staining of fetal cerebral WM showed that the development from the E69 group to the E85 group, and the E85 group to the E114 group corresponded with myelin gliosis and myelination, respectively. FA values can be used to quantify anisotropy of the different cerebral WM areas. FA values did not change significantly between 1/2 way and 3/4 of the way through gestation but was then increased dramatically at term, which could be explained by myelin gliosis and myelination ,respectively.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 67%
Professor 2 33%
Readers by discipline Count As %
Medicine and Dentistry 3 50%
Neuroscience 2 33%
Immunology and Microbiology 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2018.
All research outputs
#11,432,079
of 12,860,000 outputs
Outputs from BMC Medical Imaging
#238
of 287 outputs
Outputs of similar age
#233,750
of 269,628 outputs
Outputs of similar age from BMC Medical Imaging
#1
of 1 outputs
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