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Nomogram for overall survival of Japanese patients with bone-metastatic prostate cancer

Overview of attention for article published in BMC Cancer, May 2015
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Title
Nomogram for overall survival of Japanese patients with bone-metastatic prostate cancer
Published in
BMC Cancer, May 2015
DOI 10.1186/s12885-015-1330-x
Pubmed ID
Authors

Yasuhide Miyoshi, Kazumi Noguchi, Masahiro Yanagisawa, Masataka Taguri, Satoshi Morita, Ichiro Ikeda, Kiyoshi Fujinami, Takeshi Miura, Kazuki Kobayashi, Hiroji Uemura

Abstract

We analyzed the relationship between prostate cancer outcomes and pretreatment clinical factors and developed a prognostic nomogram of overall survival (OS) of patients with bone metastasis. From 1993 to 2011, 463 consecutive patients were treated for bone-metastatic prostate cancer. Data sets from 361 patients were used to develop a nomogram (training data), and data sets of 102 patients were used for validation of the nomogram (validation data). Using the external validation data set, the nomogram was assessed for discriminatory ability, and the predictions were assessed for calibration accuracy by plotting actual survival against predicted risk. Of the 361 patients in the training data set, 205 (56.8%) patients died, 169 (46.8%) deaths of which were due to prostate cancer. The median follow-up period was 55.2 months. In the multivariate analysis, patient age, serum prostate-specific antigen level, clinical T stage, extent of disease on bone scan, and biopsy Gleason sum were independent prognostic factors. We developed a prognostic model comprising these five factors for patients with bone-metastatic prostate cancer. This nomogram can be used to estimate 1-, 3-, and 5-year survival probability. External validation of this model using 102 validation data sets showed reasonable accuracy (concordance index, 0.719). Our pretreatment prognostic nomogram might be useful for Japanese patients with bone-metastatic prostate cancer.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 13%
Researcher 4 13%
Student > Doctoral Student 4 13%
Other 3 10%
Student > Ph. D. Student 3 10%
Other 6 20%
Unknown 6 20%
Readers by discipline Count As %
Medicine and Dentistry 13 43%
Nursing and Health Professions 2 7%
Agricultural and Biological Sciences 1 3%
Mathematics 1 3%
Psychology 1 3%
Other 3 10%
Unknown 9 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2015.
All research outputs
#18,409,030
of 22,803,211 outputs
Outputs from BMC Cancer
#5,421
of 8,297 outputs
Outputs of similar age
#192,630
of 264,364 outputs
Outputs of similar age from BMC Cancer
#183
of 251 outputs
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