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One-dimensional proteomic profiling of Danio rerio embryo vitellogenin to estimate quantum dot toxicity

Overview of attention for article published in Proteome Science, May 2015
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Title
One-dimensional proteomic profiling of Danio rerio embryo vitellogenin to estimate quantum dot toxicity
Published in
Proteome Science, May 2015
DOI 10.1186/s12953-015-0072-7
Pubmed ID
Authors

Natalia A Petushkova, Galina P Kuznetsova, Olesya V Larina, Yulia S Kisrieva, Natalia F Samenkova, Oxana P Trifonova, Yuliana V Miroshnichenko, Konstantin V Zolotarev, Irina I Karuzina, Olga M Ipatova, Andrey V Lisitsa

Abstract

Vitellogenin (Vtg) is the major egg yolk protein (YP) in most oviparous species and may be useful as an indicator in ecotoxicological testing at the biochemical level. In this study, we obtained detailed information about the Vtgs of Danio rerio embryos by cutting SDS-PAGE gel lanes into thin slices, and analyzing them slice-by-slice with (MALDI-TOF) mass spectrometry. We conducted three proteomic analyses, comparing embryonic Danio rerio Vtg cleavage products after exposure for 48 h to CdSecore/ZnSshell quantum dots (QDs), after exposure to a mixture of the components used for quantum dot synthesis (MCS-QDs), and in untreated embryos. The Vtg mass spectrometric profiles of the QDs-treated embryos differed from those of the unexposed or MCS-QDs-treated embryos. This study demonstrates the possible utility of Vtg profiling in D. rerio embryos as a sensitive diagnostic tool to estimate nanoparticle toxicity.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Philippines 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 25%
Student > Ph. D. Student 3 19%
Researcher 2 13%
Student > Bachelor 2 13%
Professor 1 6%
Other 2 13%
Unknown 2 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 25%
Environmental Science 3 19%
Biochemistry, Genetics and Molecular Biology 2 13%
Chemical Engineering 1 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 4 25%
Unknown 1 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2015.
All research outputs
#15,331,767
of 22,803,211 outputs
Outputs from Proteome Science
#102
of 190 outputs
Outputs of similar age
#156,956
of 264,370 outputs
Outputs of similar age from Proteome Science
#2
of 2 outputs
Altmetric has tracked 22,803,211 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 190 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,370 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.