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Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract

Overview of attention for article published in BMC Complementary and Alternative Medicine, March 2015
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1 tweeter

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Title
Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract
Published in
BMC Complementary and Alternative Medicine, March 2015
DOI 10.1186/s12906-015-0575-x
Pubmed ID
Authors

Al-Shwyeh Hussah Abdullah, Abdulkarim Sabo Mohammed, Abdullah Rasedee, Mohamed Elwathig Saeed Mirghani, Mothanna Sadiq Al-Qubaisi

Abstract

In this study, the effect of mango kernel extract in the induction of apoptosis of the breast cancer (MDA-MB-231) cell line was examined. This is an attempt to discover alternatives to current therapeutic regimes in the treatment of breast cancers. The pro-apoptotic markers, Bax, cytochrome c, caspases-. -8 and -9, and anti-apoptotic markers, Bcl-2, p53 and glutathione were determined in MDA-MB231 cells treated for 12 and 24 h with mango kernel extract. The results showed that the extract produced a time- and dose-dependent increases in pro-apoptotic proteins and oxidative stress markers with a corresponding decrease in anti-apoptotic markers. Based on the findings, mango kernel extract modulates redox balance in MDA-MB-231 breast cancer cells with a tendency for apoptotic cell death. The changes observed in this study may collectively underlie the basis for the cell death induced in MDA-MB-231 breast cancer cells by mango kernel extract. Thus, mango kernel extract has potential to be developed into an antibreast cancer mixture, and hence these results are worth studying further.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 22%
Researcher 7 19%
Student > Bachelor 6 16%
Student > Doctoral Student 3 8%
Student > Master 3 8%
Other 6 16%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 24%
Pharmacology, Toxicology and Pharmaceutical Science 5 14%
Medicine and Dentistry 5 14%
Biochemistry, Genetics and Molecular Biology 4 11%
Chemistry 3 8%
Other 4 11%
Unknown 7 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2015.
All research outputs
#13,035,686
of 16,413,306 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,984
of 2,967 outputs
Outputs of similar age
#162,080
of 232,458 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#1
of 1 outputs
Altmetric has tracked 16,413,306 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,967 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,458 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them