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Molecular epidemiology and seroprevalence in asymptomatic Plasmodium falciparum infections of Malagasy pregnant women in the highlands

Overview of attention for article published in Malaria Journal, May 2015
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Title
Molecular epidemiology and seroprevalence in asymptomatic Plasmodium falciparum infections of Malagasy pregnant women in the highlands
Published in
Malaria Journal, May 2015
DOI 10.1186/s12936-015-0704-5
Pubmed ID
Authors

Oumou Maïga-Ascofaré, Raphael Rakotozandrindrainy, Mirko Girmann, Andreas Hahn, Njary Randriamampionona, Sven Poppert, Jürgen May, Norbert G Schwarz

Abstract

Malaria epidemiology in Madagascar is classified into four different areas, ranging from unstable seasonal transmission in the highlands to hyperendemic perennial transmission areas in the costal level. Most malaria studies in Madagascar are focused on symptomatic children. However, because of the low transmission in some areas with correspondingly low level of semi-immunity, adults are also at risk, in particular pregnant women. The objective of this study was to gain information on the genetic epidemiology of malarial infections in pregnant women in order to provide information for malaria control and elimination programmes in Madagascar. Between May and August 2010, we made cross-sectional surveys targeting healthy pregnant women in six locations, three in the coastal area and three in the highlands at 850-1300 m. 1244 blood samples were screened for anti-Plasmodium falciparum antibodies by immunofluorescence test and for malarial infection by realtime-PCR. The prevalence of chloroquine and sulphadoxine-pyrimethamine resistance markers was also determined in all Plasmodium falciparum samples by PCR-RFLP as well as the multiplicity of infection through genotyping six neutral microsatellites. In the highlands, 67.4% of the women presented antibodies against Plasmodium falciparum and 9.2% were carrying parasites, at the coast 95.6% and 14.8%, respectively. In the mean, 1.2 clones were detected in infected pregnant woman in the highlands and 1.5 at the coast. A higher level of monoclonal infections was found in the highlands (85.4%) compared to the coast (61.8%). Resistance markers for sulphadoxine-pyrimethamine were present only in two sites. Malaria parasites in human Madagascan highland populations trigger immunity but could also be a reservoir for malaria epidemics.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Madagascar 2 2%
Spain 1 1%
Unknown 84 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 20%
Researcher 18 20%
Student > Ph. D. Student 10 11%
Student > Doctoral Student 7 8%
Student > Bachelor 5 6%
Other 17 19%
Unknown 14 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 19%
Medicine and Dentistry 16 18%
Biochemistry, Genetics and Molecular Biology 10 11%
Nursing and Health Professions 4 4%
Social Sciences 4 4%
Other 19 21%
Unknown 19 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2015.
All research outputs
#13,434,323
of 22,803,211 outputs
Outputs from Malaria Journal
#3,518
of 5,562 outputs
Outputs of similar age
#127,271
of 264,285 outputs
Outputs of similar age from Malaria Journal
#60
of 114 outputs
Altmetric has tracked 22,803,211 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,562 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,285 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 114 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.