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Quetiapine-associated leucopenia and thrombocytopenia: a case report

Overview of attention for article published in BMC Psychiatry, May 2015
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Title
Quetiapine-associated leucopenia and thrombocytopenia: a case report
Published in
BMC Psychiatry, May 2015
DOI 10.1186/s12888-015-0495-9
Pubmed ID
Authors

Kuang-Yuan Fan, Wen-Yin Chen, Ming-Chyi Huang

Abstract

There have been few reports regarding quetiapine-associated hematological effects other than white-blood-cell alteration. We present the first reported Han-Chinese case that developed leucopenia and thrombocytopenia after taking quetiapine. We present a case of a person with a bipolar I disorder who experienced leucopenia and thrombocytopenia after taking 400 mg/day of quetiapine and 1000 mg/day of valproic acid for three and one-half months. The hematological toxicity abated upon the discontinuation of both drugs. However, due to the intolerable side effects of the replaced antipsychotic (haloperidol), and according to the patient's preference, we prescribed quetiapine and valproic acid again. There was a recurrence of leucopenia and a decreased platelet count by the sixth day. The adverse effects disappeared soon after we discontinued quetiapine, while keeping valproic acid treatment. Quetiapine-associated leucopenia and thrombocytopenia seems reversible but possibly fatal. Therefore, clinical practitioners should be aware of this adverse reaction.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 16%
Other 4 13%
Student > Master 4 13%
Researcher 4 13%
Student > Doctoral Student 3 10%
Other 7 23%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 14 45%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Neuroscience 2 6%
Agricultural and Biological Sciences 2 6%
Social Sciences 2 6%
Other 2 6%
Unknown 6 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2015.
All research outputs
#20,271,607
of 22,803,211 outputs
Outputs from BMC Psychiatry
#4,208
of 4,684 outputs
Outputs of similar age
#222,641
of 264,554 outputs
Outputs of similar age from BMC Psychiatry
#65
of 74 outputs
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