Title |
The difficult management of disseminated Sporothrix brasiliensis in a patient with advanced AIDS
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Published in |
AIDS Research and Therapy, May 2015
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DOI | 10.1186/s12981-015-0051-1 |
Pubmed ID | |
Authors |
Ariane Gomes Paixão, Maria Clara Gutierrez Galhardo, Rodrigo Almeida-Paes, Estevão Portela Nunes, Marcelo Luiz Carvalho Gonçalves, Gisele Larias Chequer, Cristiane da Cruz Lamas |
Abstract |
Sporotrichosis is an infection caused by a dimorphic fungus of the Sporothrix schenckii complex. Host immunity is an important factor in the clinical manifestations of the disease. Deeply immunocompromised individuals, especially those infected with the Human Immunodeficiency Virus (HIV) and T CD4 counts < 350 cells/ul lymphocytes, may present with the systemic form of sporotrichosis. This report describes a case of disseminated sporotrichosis caused by S. brasiliensis in a patient with advanced AIDS. The skin, lungs, bones and central nervous system were affected. Medical treatment involved the administration of amphotericin B, terbinafine, itraconazole and posaconazole. Posaconazole was associated with the best clinical response and clearing of the fungus from the central nervous system. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 2% |
Unknown | 43 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 23% |
Student > Postgraduate | 7 | 16% |
Student > Bachelor | 6 | 14% |
Student > Ph. D. Student | 3 | 7% |
Student > Doctoral Student | 2 | 5% |
Other | 6 | 14% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 32% |
Agricultural and Biological Sciences | 4 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Veterinary Science and Veterinary Medicine | 2 | 5% |
Other | 6 | 14% |
Unknown | 12 | 27% |