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A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population

Overview of attention for article published in BMC Gastroenterology, May 2015
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Title
A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population
Published in
BMC Gastroenterology, May 2015
DOI 10.1186/s12876-015-0286-2
Pubmed ID
Authors

Jing Chen, Wei Wang, Xiaoguang Li, Jie Xu

Abstract

Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis. Search the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population and Chinese population under an additive genetic model by STATA11.0. The pooled odds ratios (OR) of rs12979860 are 0.79 (95%CI, 0.53-1.18; P = 0.25, I(2) = 63.2%) and 1.62 (95%CI, 1.04-2.51; P = 0.033, I(2) = 54.3%) respectively in Asian population and Chinese population analysis. The pooled OR of rs8099917 are 1.05 (95%CI, 0.93-1.19; P = 0.44, I(2) = 43.3%) and 0.97 (95%CI, 0.84-1.23; P = 0.726, I(2) = 15.6%) respectively in Asian population and Chinese population analysis. Our study demonstrated that T allele of rs12979680 can increase the risk of HBV infection in Chinese population but not Asian population under an additive genetic model. There is no association between rs8099917 and HBV infection in Chinese population and Asian population.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 18%
Student > Ph. D. Student 2 18%
Researcher 2 18%
Student > Master 1 9%
Student > Postgraduate 1 9%
Other 0 0%
Unknown 3 27%
Readers by discipline Count As %
Medicine and Dentistry 4 36%
Biochemistry, Genetics and Molecular Biology 1 9%
Immunology and Microbiology 1 9%
Nursing and Health Professions 1 9%
Unknown 4 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2015.
All research outputs
#15,331,767
of 22,803,211 outputs
Outputs from BMC Gastroenterology
#830
of 1,744 outputs
Outputs of similar age
#156,513
of 264,485 outputs
Outputs of similar age from BMC Gastroenterology
#17
of 27 outputs
Altmetric has tracked 22,803,211 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,744 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,485 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.