Title |
HaploShare: identification of extended haplotypes shared by cases and evaluation against controls
|
---|---|
Published in |
Genome Biology, May 2015
|
DOI | 10.1186/s13059-015-0662-9 |
Pubmed ID | |
Authors |
Dingge Ying, Pak Chung Sham, David Keith Smith, Lu Zhang, Yu Lung Lau, Wanling Yang |
Abstract |
Recent founder mutations may play important roles in complex diseases and Mendelian disorders. Detecting shared haplotypes that are identical by descent (IBD) could facilitate discovery of these mutations. Several programs address this, but are usually limited to detecting pair-wise shared haplotypes and not providing a comparison of cases and controls. We present a novel algorithm and software package, HaploShare, which detects extended haplotypes that are shared by multiple individuals, and allows comparisons between cases and controls. Testing on simulated and real cases demonstrated significant improvements in detection power and reduction of false positive rate by HaploShare relative to other programs. |
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