Title |
Do human tumor-associated viruses play a role in the development of synovial sarcoma?
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Published in |
Clinical Sarcoma Research, April 2015
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DOI | 10.1186/s13569-015-0027-x |
Pubmed ID | |
Authors |
Ulrich Lenze, Florian Pohlig, Heinrich Mühlhofer, Florian Lenze, Andreas Toepfer, Hans Rechl, Rainer Burgkart, Rüdiger von Eisenhart-Rothe, Melanie Straub |
Abstract |
To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas. In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected. An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities. |
X Demographics
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 20% |
Student > Bachelor | 1 | 10% |
Student > Master | 1 | 10% |
Unknown | 6 | 60% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 40% |
Social Sciences | 1 | 10% |
Unknown | 5 | 50% |