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Increased serum resistin levels correlate with psoriasis: a meta-analysis

Overview of attention for article published in Lipids in Health and Disease, May 2015
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Title
Increased serum resistin levels correlate with psoriasis: a meta-analysis
Published in
Lipids in Health and Disease, May 2015
DOI 10.1186/s12944-015-0039-9
Pubmed ID
Authors

Huiyun Huang, Erdong Shen, Shiqing Tang, Xingyou Tan, Xiuli Guo, Qiang Wang, Hongwei Ding

Abstract

Recent studies implicate adipokines in the pathogenesis of inflammatory diseases, including psoriasis. In this study we evaluated the significance of serum resistin levels in psoriasis patients using a meta-analysis approach. Relevant articles were retrieved by searching the following English and Chinese databases: Cochrane Library, PubMed, Springer Link, Chinese Biomedical Database (CBM) and Chinese National Knowledge Infrastructure (CNKI). The retrieved studies were subjected to a thorough screening procedure to identify case-control studies that contained the required data. Data was extracted from each study and Version 12.0 STATA statistical software was employed for statistical analyses. Nine case-control studies, containing 421 psoriasis patients and 348 healthy controls, were included in this study. The major result of the meta-analysis revealed a statistically significant association between serum resistin levels and psoriasis (SMD = 2.22, 95%CI: 1.14-3.29, P < 0.001). Subgroup analysis based on ethnicity showed that, compared to the healthy controls, serum resistin levels were markedly higher in psoriasis patients in both Asian and Caucasian populations (Asians: SMD = 3.27, 95%CI = 1.62 ~ 4.91, P < 0.001; Caucasians: SMD = 0.91, 95%CI = 0.28 ~ 1.54, P < 0.001). Based on our results, we conclude that serum resistin level in psoriasis patients is higher than healthy controls, and raises the possibility that elevated serum resistin levels may be a novel diagnostic marker in psoriasis and may predict the occurrence of co-morbidities in psoriasis patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 16%
Student > Ph. D. Student 4 16%
Lecturer 2 8%
Student > Doctoral Student 2 8%
Student > Bachelor 2 8%
Other 8 32%
Unknown 3 12%
Readers by discipline Count As %
Medicine and Dentistry 9 36%
Agricultural and Biological Sciences 3 12%
Unspecified 2 8%
Environmental Science 1 4%
Business, Management and Accounting 1 4%
Other 3 12%
Unknown 6 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2015.
All research outputs
#20,273,512
of 22,805,349 outputs
Outputs from Lipids in Health and Disease
#1,202
of 1,449 outputs
Outputs of similar age
#222,502
of 265,295 outputs
Outputs of similar age from Lipids in Health and Disease
#15
of 21 outputs
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