Title |
Conditional deletion of epithelial IKKβ impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis
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Published in |
Respiratory Research, December 2011
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DOI | 10.1186/1465-9921-12-134 |
Pubmed ID | |
Authors |
Vedang A Londhe, Tiffany M Maisonet, Benjamin Lopez, Jade-Ming Jeng, Jing Xiao, Changgong Li, Parviz Minoo |
Abstract |
Alveolar septation marks the beginning of the transition from the saccular to alveolar stage of lung development. Inflammation can disrupt this process and permanently impair alveolar formation resulting in alveolar hypoplasia as seen in bronchopulmonary dysplasia in preterm newborns. NF-κB is a transcription factor central to multiple inflammatory and developmental pathways including dorsal-ventral patterning in fruit flies; limb, mammary and submandibular gland development in mice; and branching morphogenesis in chick lungs. We have previously shown that epithelial overexpression of NF-κB accelerates lung maturity using transgenic mice. The purpose of this study was to test our hypothesis that targeted deletion of NF-κB signaling in lung epithelium would impair alveolar formation. |
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 24% |
Researcher | 5 | 24% |
Student > Doctoral Student | 2 | 10% |
Student > Master | 2 | 10% |
Professor > Associate Professor | 2 | 10% |
Other | 2 | 10% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 29% |
Agricultural and Biological Sciences | 5 | 24% |
Biochemistry, Genetics and Molecular Biology | 4 | 19% |
Social Sciences | 1 | 5% |
Psychology | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 19% |