Title |
The genetic validation of heterogeneity in schizophrenia
|
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Published in |
Behavioral and Brain Functions, October 2011
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DOI | 10.1186/1744-9081-7-43 |
Pubmed ID | |
Authors |
Atsushi Tsutsumi, Stephen J Glatt, Tetsufumi Kanazawa, Seiya Kawashige, Hiroyuki Uenishi, Akira Hokyo, Takao Kaneko, Makiko Moritani, Hiroki Kikuyama, Jun Koh, Hitoshi Matsumura, Hiroshi Yoneda |
Abstract |
Schizophrenia is a heritable disorder, however clear genetic architecture has not been detected. To overcome this state of uncertainty, the SZGene database has been established by including all published case-control genetic association studies appearing in peer-reviewed journals. In the current study, we aimed to determine if genetic variants strongly suggested by SZGene are associated with risk of schizophrenia in our case-control samples of Japanese ancestry. In addition, by employing the additive model for aggregating the effect of seven variants, we aimed to verify the genetic heterogeneity of schizophrenia diagnosed by an operative diagnostic manual, the DSM-IV. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 3 | 9% |
Brazil | 1 | 3% |
Unknown | 29 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 15% |
Student > Postgraduate | 5 | 15% |
Student > Ph. D. Student | 4 | 12% |
Student > Bachelor | 3 | 9% |
Student > Master | 3 | 9% |
Other | 10 | 30% |
Unknown | 3 | 9% |
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Biochemistry, Genetics and Molecular Biology | 5 | 15% |
Agricultural and Biological Sciences | 4 | 12% |
Psychology | 4 | 12% |
Neuroscience | 2 | 6% |
Other | 3 | 9% |
Unknown | 6 | 18% |