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Optimization of genomic selection training populations with a genetic algorithm

Overview of attention for article published in Genetics Selection Evolution, May 2015
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Title
Optimization of genomic selection training populations with a genetic algorithm
Published in
Genetics Selection Evolution, May 2015
DOI 10.1186/s12711-015-0116-6
Pubmed ID
Authors

Deniz Akdemir, Julio I Sanchez, Jean-Luc Jannink

Abstract

In this article, we imagine a breeding scenario with a population of individuals that have been genotyped but not phenotyped. We derived a computationally efficient statistic that uses this genetic information to measure the reliability of genomic estimated breeding values (GEBV) for a given set of individuals (test set) based on a training set of individuals. We used this reliability measure with a genetic algorithm scheme to find an optimized training set from a larger set of candidate individuals. This subset was phenotyped to create the training set that was used in a genomic selection model to estimate GEBV in the test set. Our results show that, compared to a random sample of the same size, the use of a set of individuals selected by our method improved accuracies. We implemented the proposed training selection methodology on four sets of data on Arabidopsis, wheat, rice and maize. This dynamic model building process that takes genotypes of the individuals in the test sample into account while selecting the training individuals improves the performance of genomic selection models.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 230 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 <1%
United States 2 <1%
Italy 1 <1%
New Zealand 1 <1%
Sweden 1 <1%
Denmark 1 <1%
Belgium 1 <1%
Unknown 221 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 52 23%
Researcher 47 20%
Student > Doctoral Student 26 11%
Student > Master 25 11%
Student > Bachelor 10 4%
Other 37 16%
Unknown 33 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 159 69%
Biochemistry, Genetics and Molecular Biology 8 3%
Mathematics 5 2%
Computer Science 4 2%
Engineering 3 1%
Other 7 3%
Unknown 44 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2016.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Genetics Selection Evolution
#667
of 822 outputs
Outputs of similar age
#206,514
of 279,099 outputs
Outputs of similar age from Genetics Selection Evolution
#19
of 23 outputs
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