Title |
Optimization of genomic selection training populations with a genetic algorithm
|
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Published in |
Genetics Selection Evolution, May 2015
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DOI | 10.1186/s12711-015-0116-6 |
Pubmed ID | |
Authors |
Deniz Akdemir, Julio I Sanchez, Jean-Luc Jannink |
Abstract |
In this article, we imagine a breeding scenario with a population of individuals that have been genotyped but not phenotyped. We derived a computationally efficient statistic that uses this genetic information to measure the reliability of genomic estimated breeding values (GEBV) for a given set of individuals (test set) based on a training set of individuals. We used this reliability measure with a genetic algorithm scheme to find an optimized training set from a larger set of candidate individuals. This subset was phenotyped to create the training set that was used in a genomic selection model to estimate GEBV in the test set. Our results show that, compared to a random sample of the same size, the use of a set of individuals selected by our method improved accuracies. We implemented the proposed training selection methodology on four sets of data on Arabidopsis, wheat, rice and maize. This dynamic model building process that takes genotypes of the individuals in the test sample into account while selecting the training individuals improves the performance of genomic selection models. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | <1% |
United States | 2 | <1% |
Italy | 1 | <1% |
New Zealand | 1 | <1% |
Sweden | 1 | <1% |
Denmark | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 221 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 23% |
Researcher | 47 | 20% |
Student > Doctoral Student | 26 | 11% |
Student > Master | 25 | 11% |
Student > Bachelor | 10 | 4% |
Other | 37 | 16% |
Unknown | 33 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 159 | 69% |
Biochemistry, Genetics and Molecular Biology | 8 | 3% |
Mathematics | 5 | 2% |
Computer Science | 4 | 2% |
Engineering | 3 | 1% |
Other | 7 | 3% |
Unknown | 44 | 19% |