Title |
A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS
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Published in |
BMC Genomics, October 2011
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DOI | 10.1186/1471-2164-12-504 |
Pubmed ID | |
Authors |
Kris Richardson, Chao-Qiang Lai, Laurence D Parnell, Yu-Chi Lee, Jose M Ordovas |
Abstract |
Gene variants within regulatory regions are thought to be major contributors of the variation of complex traits/diseases. Genome wide association studies (GWAS), have identified scores of genetic variants that appear to contribute to human disease risk. However, most of these variants do not appear to be functional. Thus, the significance of the association may be brought up by still unknown mechanisms or by linkage disequilibrium (LD) with functional polymorphisms. In the present study, focused on functional variants related with the binding of microRNAs (miR), we utilized SNP data, including newly released 1000 Genomes Project data to perform a genome-wide scan of SNPs that abrogate or create miR recognition element (MRE) seed sites (MRESS). |
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Geographical breakdown
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United Kingdom | 1 | 6% |
Canada | 1 | 6% |
Unknown | 12 | 67% |
Demographic breakdown
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Members of the public | 12 | 67% |
Scientists | 7 | 39% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 2 | 2% |
United Kingdom | 2 | 2% |
Brazil | 2 | 2% |
Italy | 1 | <1% |
Norway | 1 | <1% |
Chile | 1 | <1% |
Canada | 1 | <1% |
France | 1 | <1% |
Other | 2 | 2% |
Unknown | 107 | 85% |
Demographic breakdown
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Student > Ph. D. Student | 30 | 24% |
Researcher | 28 | 22% |
Student > Master | 14 | 11% |
Professor > Associate Professor | 13 | 10% |
Student > Doctoral Student | 8 | 6% |
Other | 27 | 21% |
Unknown | 6 | 5% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 20 | 16% |
Medicine and Dentistry | 10 | 8% |
Computer Science | 7 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 6 | 5% |
Unknown | 10 | 8% |