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Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria

Overview of attention for article published in BMC Molecular and Cell Biology, April 2015
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Title
Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria
Published in
BMC Molecular and Cell Biology, April 2015
DOI 10.1186/s12858-015-0040-y
Pubmed ID
Authors

Nino Natsvlishvili, Nino Goguadze, Elene Zhuravliova, David Mikeladze

Abstract

Small Rho-GTPases are critical mediators of neuronal plasticity and are involved in the pathogenesis of several psychiatric and neurological disorders. Rac-GTPase forms a multiprotein complex with upstream and downstream regulators that are essential for the spatiotemporal transmission of Rac signaling. The sigma-1 receptor (Sig1R) is a ligand-regulated membrane protein chaperone, and multiprotein complex assembly is essential to sigma-receptor function. Using immunoprecipitation techniques, we have shown that in mitochondrial membranes Sig1R could directly interact with Rac1. Besides Rac1, the Sig1R forms complexes with inositol 1,4,5-trisphosphate receptor and Bcl2, suggesting that mitochondrial associated membranes (MAM) are involved in this macromolecular complex formation. Assembly of this complex is ligand-specific and depends on the presence of sigma agonist/antagonist, as well as on the presence of GTP/GDP. Treatment of mitochondrial membranes with (+)-pentazocine leads to the (+)-pentazocine-sensitive phosphorylation of Bad and the pentazocine-sensitive NADPH-dependent production of ROS. We suggest that Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity, as well as in the prevention of apoptosis and autophagy.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 15%
Student > Ph. D. Student 7 13%
Student > Master 6 11%
Student > Bachelor 6 11%
Professor 3 6%
Other 8 15%
Unknown 15 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 23%
Agricultural and Biological Sciences 7 13%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Neuroscience 4 8%
Chemistry 3 6%
Other 5 9%
Unknown 17 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2015.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from BMC Molecular and Cell Biology
#1,054
of 1,233 outputs
Outputs of similar age
#239,042
of 278,542 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#13
of 19 outputs
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So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.