You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
CCR5 facilitates endothelial progenitor cell recruitment and promotes the stabilization of atherosclerotic plaques in ApoE−/− mice
|
|---|---|
| Published in |
Stem Cell Research & Therapy, March 2015
|
| DOI | 10.1186/s13287-015-0026-0 |
| Pubmed ID | |
| Authors |
Zhongwen Zhang, Jianjun Dong, Corrinne G Lobe, Peiyun Gong, Ju Liu, Lin Liao |
| Abstract |
Unstable atherosclerotic plaques are prone to rupture, which leads to atherothrombosis. Endothelial progenitor cells (EPCs) are bone marrow (BM)-derived precursor cells that may repair vascular injury in atherosclerosis. Chemokine (C-C motif) receptor 5 (CCR5) promotes mobilization of EPCs. In this study, we investigated the therapeutic potential of CCR5 overexpressing EPCs on plaques stabilization in apolipoprotein E (ApoE)(-/-) mouse model. The expression of CCR5 and its cognate ligand chemokine (C-C motif) ligand 5 (CCL5) were examined in atherosclerotic aortas of human and mice by immunohistochemistry. Splenectomized ApoE(-/-) C57BL/6 J mice fed with high-fat diet for 24 weeks were intravenously injected with EPCs transfected with CCR5 overexpression lentivirus. The recruitment of EPCs over the atherosclerotic plaques was evaluated by immunofluorescence. The content of lipid, smooth muscle cells, monocytes/macrophages, and endothelial cells in atherosclerotic plaques were assayed by specific immunostaining. The serum levels of atherosclerosis-related inflammatory factors in ApoE(-/-) mice were measured by a mouse atherosclerosis antibody array I. CCR5 and CCL5 are highly expressed in atherosclerotic plaques in both human and mice. The ApoE(-/-) mice with CCR5 overexpressing EPC treatment demonstrated a more stability plaques formation with enhanced recruitment of EPCs, reduced lipids and macrophages content in the atherosclerotic plaques. CCR5 overexpressing EPCs treatment also increased the content of endothelial cells and nitric oxide (NO) production in the plaques. In addition, the serum levels of interleukin 3 (IL-3), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 13(IL-13), CD40 and tumor necrosis factor-alpha (TNF-alpha), and the plaques contents of IL-6 and matrix metalloproteinase 9 (MMP9) were reduced in mice with CCR5 overexpressing EPC treatment. These findings suggest that CCR5 is a novel therapeutic target in EPC treatment for stabilization of atherosclerotic plaques. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 18% |
| Student > Postgraduate | 4 | 14% |
| Researcher | 4 | 14% |
| Other | 3 | 11% |
| Student > Master | 2 | 7% |
| Other | 6 | 21% |
| Unknown | 4 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 36% |
| Biochemistry, Genetics and Molecular Biology | 7 | 25% |
| Unspecified | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 6 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2016.
All research outputs
#14,496,834
of 23,656,895 outputs
Outputs from Stem Cell Research & Therapy
#1,087
of 2,505 outputs
Outputs of similar age
#136,853
of 264,843 outputs
Outputs of similar age from Stem Cell Research & Therapy
#28
of 64 outputs
Altmetric has tracked 23,656,895 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,505 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,843 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.