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Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical…

Overview of attention for article published in BMC Gastroenterology, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
1 blog
twitter
4 tweeters

Citations

dimensions_citation
63 Dimensions

Readers on

mendeley
131 Mendeley
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Title
Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial
Published in
BMC Gastroenterology, March 2015
DOI 10.1186/s12876-015-0260-z
Pubmed ID
Authors

Zhihua Liu, Chao Li, Meijin Huang, Chao Tong, Xingwei Zhang, Lei Wang, Hui Peng, Ping Lan, Peng Zhang, Nanqi Huang, Junsheng Peng, Xiaojian Wu, Yanxing Luo, Huanlong Qin, Liang Kang, Jianping Wang

Abstract

Colorectal liver metastases (CLM) occur frequently and postoperative intestinal infection is a common complication. Our previous study showed that probiotics could decrease the rate of infectious complications after colectomy for colorectal cancer. To determine the effects of the perioperative administration of probiotics on serum zonulin levels which is a marker of intestinal permeability and the subsequent impact on postoperative infectious complications in patients with CLM. 150 patients with CLM were randomly divided into control group (n = 68) and probiotics group (n = 66). Probiotics and placebo were given orally for 6 days preoperatively and 10 days postoperatively to control group and probiotics group respectively. We used the local resection for metastatic tumor ,while for large tumor, the segmental hepatectomy. Postoperative outcome were recorded. Furthermore, complications in patients with normal intestinal barrier function and the relation with serum zonulin were analyzed to evaluate the impact on the liver barrier dysfunction. The incidence of infectious complications in the probiotics group was lower than control group. Analysis of CLM patients with normal postoperative intestinal barrier function paralleled with the serum zonulin level. And probiotics could also reduce the concentration of serum zonulin (P = 0.004) and plasma endotoxin (P < 0.001). Perioperative probiotics treatment could reduce the serum zonulin level, the rate of postoperative septicemia and maintain the liver barrier in patients undergoing CLM surgery. we propose a new model about the regulation of probiotics to liver barrier via clinical regulatory pathway. We recommend the preoperative oral intake of probiotics combined with postoperative continued probiotics treatment in patients who undergo CLM surgery. ChiCTR-TRC- 12002841 . 2012/12/21.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Tanzania, United Republic of 1 <1%
Unknown 130 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 21 16%
Student > Bachelor 16 12%
Other 15 11%
Researcher 13 10%
Student > Ph. D. Student 12 9%
Other 20 15%
Unknown 34 26%
Readers by discipline Count As %
Medicine and Dentistry 48 37%
Biochemistry, Genetics and Molecular Biology 11 8%
Nursing and Health Professions 9 7%
Agricultural and Biological Sciences 5 4%
Pharmacology, Toxicology and Pharmaceutical Science 4 3%
Other 8 6%
Unknown 46 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2016.
All research outputs
#1,005,032
of 8,600,861 outputs
Outputs from BMC Gastroenterology
#53
of 696 outputs
Outputs of similar age
#35,357
of 220,616 outputs
Outputs of similar age from BMC Gastroenterology
#2
of 25 outputs
Altmetric has tracked 8,600,861 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 696 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 220,616 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.