Title |
Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection
|
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Published in |
BMC Biology, April 2015
|
DOI | 10.1186/s12915-015-0129-1 |
Pubmed ID | |
Authors |
Mark W Pellegrino, Cole M Haynes |
Abstract |
Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkinson's disease, as well as bacterial infection. Here, we explore the roles of mitochondrial autophagy (mitophagy) and the mitochondrial unfolded protein response (UPRmt) in the response to mitochondrial dysfunction, focusing in particular on recent evidence on the role of mitochondrial import efficiency in the regulation of these stress pathways and how they may interact to protect the mitochondrial pool while initiating an innate immune response to protect against bacterial pathogens. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
United States | 2 | <1% |
Switzerland | 1 | <1% |
Unknown | 201 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 25% |
Researcher | 35 | 17% |
Student > Bachelor | 24 | 12% |
Student > Master | 21 | 10% |
Student > Doctoral Student | 9 | 4% |
Other | 28 | 14% |
Unknown | 37 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 74 | 36% |
Biochemistry, Genetics and Molecular Biology | 52 | 25% |
Neuroscience | 15 | 7% |
Medicine and Dentistry | 8 | 4% |
Immunology and Microbiology | 8 | 4% |
Other | 14 | 7% |
Unknown | 35 | 17% |