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Attention Score in Context
| Title |
Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation
|
|---|---|
| Published in |
Acta Neuropathologica Communications, April 2015
|
| DOI | 10.1186/s40478-015-0193-3 |
| Pubmed ID | |
| Authors |
Jochen Martin Decker, Lars Krüger, Astrid Sydow, Shanting Zhao, Michael Frotscher, Eckhard Mandelkow, Eva-Maria Mandelkow |
| Abstract |
We used an inducible mouse model expressing the Tau repeat domain with the pro-aggregant mutation ΔK280 to analyze presynaptic Tau pathology in the hippocampus. Expression of pro-aggregant TauRDΔ leads to phosphorylation, aggregation and missorting of Tau in area CA3. To test presynaptic pathophysiology we used electrophysiology in the mossy fiber tract. Synaptic transmission was severely disturbed in pro-aggregant TauRDΔ and Tau-knockout mice. Long-term depression of the mossy fiber tract failed in pro-aggregant TauRDΔ mice. We observed an increase in bouton size, but a decline in numbers and presynaptic markers. Both pre-and postsynaptic structural deficits are preventable by inhibition of TauRDΔ aggregation. Calcium imaging revealed progressive calcium dysregulation in boutons of pro-aggregant TauRDΔ mice. In N2a cells we observed this even in cells without tangle load, whilst in primary hippocampal neurons transient TauRDΔ expression alone caused similar Ca++ dysregulation. Ultrastructural analysis revealed a severe depletion of synaptic vesicles pool in accordance with synaptic transmission impairments. We conclude that oligomer formation by TauRDΔ causes pre- and postsynaptic structural deterioration and Ca++ dysregulation which leads to synaptic plasticity deficits. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 105 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 30% |
| Researcher | 18 | 17% |
| Student > Bachelor | 13 | 12% |
| Student > Master | 11 | 10% |
| Professor | 5 | 5% |
| Other | 8 | 8% |
| Unknown | 19 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 35 | 33% |
| Biochemistry, Genetics and Molecular Biology | 21 | 20% |
| Agricultural and Biological Sciences | 16 | 15% |
| Medicine and Dentistry | 3 | 3% |
| Chemistry | 2 | 2% |
| Other | 7 | 7% |
| Unknown | 22 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2015.
All research outputs
#15,333,503
of 22,805,349 outputs
Outputs from Acta Neuropathologica Communications
#1,135
of 1,372 outputs
Outputs of similar age
#157,467
of 264,201 outputs
Outputs of similar age from Acta Neuropathologica Communications
#11
of 15 outputs
Altmetric has tracked 22,805,349 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,372 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,201 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.