Title |
Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue
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Published in |
BMC Cancer, October 2011
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DOI | 10.1186/1471-2407-11-445 |
Pubmed ID | |
Authors |
Patrizio Castagnola, Davide Malacarne, Paola Scaruffi, Massimo Maffei, Alessandra Donadini, Emanuela Di Nallo, Simona Coco, Gian Paolo Tonini, Monica Pentenero, Sergio Gandolfo, Walter Giaretti |
Abstract |
The mucosae of the oral cavity are different at the histological level but appear all equally exposed to common genotoxic agents. As a result of this exposure, changes in the mucosal epithelia may develop giving rise to Oral Potentially Malignant Lesions (OPMLs), which with time may in turn progress to Oral Squamous Cell Carcinomas (OSCCs). Therefore, much effort should be devoted to identify features able to predict the likeliness of progression associated with an OPML. Such features may be helpful in assisting the clinician to establish both appropriate therapies and follow-up schedules. Here, we report a pilot study that compared the occurrence of DNA aneuploidy and chromosomal copy number aberrations (CNAs) in the OPMLs from different oral anatomical subsites. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 3% |
India | 1 | 3% |
Unknown | 28 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor > Associate Professor | 6 | 20% |
Student > Master | 6 | 20% |
Student > Ph. D. Student | 4 | 13% |
Professor | 3 | 10% |
Student > Postgraduate | 2 | 7% |
Other | 4 | 13% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 33% |
Agricultural and Biological Sciences | 5 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Psychology | 2 | 7% |
Business, Management and Accounting | 1 | 3% |
Other | 3 | 10% |
Unknown | 6 | 20% |