Title |
Plasma proteome analysis in HTLV-1-associated myelopathy/tropical spastic paraparesis
|
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Published in |
Retrovirology, October 2011
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DOI | 10.1186/1742-4690-8-81 |
Pubmed ID | |
Authors |
Paul DW Kirk, Aviva Witkover, Alan Courtney, Alexandra M Lewin, Robin Wait, Michael PH Stumpf, Sylvia Richardson, Graham P Taylor, Charles RM Bangham |
Abstract |
Human T lymphotropic virus Type 1 (HTLV-1) causes a chronic inflammatory disease of the central nervous system known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM) which resembles chronic spinal forms of multiple sclerosis (MS). The pathogenesis of HAM remains uncertain. To aid in the differential diagnosis of HAM and to identify pathogenetic mechanisms, we analysed the plasma proteome in asymptomatic HTLV-1 carriers (ACs), patients with HAM, uninfected controls, and patients with MS. We used surface-enhanced laser desorption-ionization (SELDI) mass spectrometry to analyse the plasma proteome in 68 HTLV-1-infected individuals (in two non-overlapping sets, each comprising 17 patients with HAM and 17 ACs), 16 uninfected controls, and 11 patients with secondary progressive MS. Candidate biomarkers were identified by tandem Q-TOF mass spectrometry. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 22% |
United Kingdom | 1 | 11% |
Argentina | 1 | 11% |
United States | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 56% |
Scientists | 3 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 20% |
Student > Ph. D. Student | 7 | 18% |
Researcher | 6 | 15% |
Student > Doctoral Student | 3 | 8% |
Other | 3 | 8% |
Other | 5 | 13% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 23% |
Agricultural and Biological Sciences | 6 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Immunology and Microbiology | 3 | 8% |
Engineering | 2 | 5% |
Other | 6 | 15% |
Unknown | 11 | 28% |