Title |
Overdose of dolutegravir in combination with tenofovir disaproxil fumarate/emtricitabine in suicide attempt in a 21-year old patient
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Published in |
AIDS Research and Therapy, May 2015
|
DOI | 10.1186/s12981-015-0054-y |
Pubmed ID | |
Authors |
Marcel Lee, Florian Eyer, Norbert Felgenhauer, Hartwig HF Klinker, Christoph D Spinner |
Abstract |
A 21 year old MSM patient with newly diagnosed HIV infection was hospitalized in our department after ingestion of an overdose of his antiretroviral therapy (ART) comprising dolutegravir (DTG - Tivicay®) and tenofovir disaproxil fumarate/emtricitabine (Truvada®) in suicidal intention. On admission, the patient did not show any clinical signs of intoxication and laboratory findings were unremarkable. After 6 hours of intensive care monitoring, the patient was referred to a psychiatric clinic. 5 days after the day of intoxication, serum creatinine levels increased to high normal values (1.2 mg/dl). However, levels never exceeded the upper threshold. 8 and 12 weeks later, serum creatinine normalized to levels measured prior to the intoxication. No other adverse events occurred, and the patient does not suffer from permanent impairments. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 6 | 18% |
Student > Master | 5 | 15% |
Student > Ph. D. Student | 3 | 9% |
Student > Bachelor | 2 | 6% |
Researcher | 2 | 6% |
Other | 5 | 15% |
Unknown | 11 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 32% |
Psychology | 4 | 12% |
Immunology and Microbiology | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 3 | 9% |
Unknown | 12 | 35% |