↓ Skip to main content

Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent

Overview of attention for article published in Molecular Autism, May 2015
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
45 Dimensions

Readers on

mendeley
73 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Regional brain volume differences between males with and without autism spectrum disorder are highly age-dependent
Published in
Molecular Autism, May 2015
DOI 10.1186/s13229-015-0022-3
Pubmed ID
Authors

Hsiang-Yuan Lin, Hsing-Chang Ni, Meng-Chuan Lai, Wen-Yih Isaac Tseng, Susan Shur-Fen Gau

Abstract

Neuroanatomical differences between individuals with and without autism spectrum disorder (ASD) were inconsistent in the literature. Such heterogeneity may substantially originate from age-differential effects. Voxel-based morphometry was applied in 86 males with ASD and 90 typically developing control (TDC) males (aged 7 to 29 years). Three steps of statistical modeling (model 1, multiple regression with age as a covariate; model 2, multiple regression further considering diagnosis-by-age interaction; model 3, age-stratified analyses) were performed to dissect the moderating effects of age on diagnostic group differences in neuroanatomy. Across ages, males with and without ASD did not differ significantly in total gray matter (GM) or white matter (WM) volumes. For both groups, total GM volumes decreased and WM volumes increased with age. For regional volume, comparing with the model only held the age constant (model 1), the main effect of group altered when diagnosis-by-age interaction effects were considered (model 2). Here, participants with ASD had significantly greater relative regional GM volumes than TDC in the right inferior orbitofrontal cortex and bilateral thalamus; for WM, participants with ASD were larger than TDC in the bilateral splenium of corpus callosum and right anterior corona radiata. Importantly, significant diagnosis-by-age interactions were identified at the bilateral anterior prefrontal cortex, bilateral cuneus, bilateral caudate, and the left cerebellum Crus I for GM and left forceps minor for WM. Finally, age-stratified analyses (model 3) showed distinct patterns in GM and WM volumetric alterations in ASD among subsamples of children, adolescents, and adults. Our findings suggest that the heterogeneous reports on the atypical neuroanatomy of ASD may substantially originate from age variation in the study samples. Age variation and its methodological and biological implications have to be carefully delineated in future studies of the neurobiology of ASD.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Canada 1 1%
Unknown 71 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 25%
Student > Ph. D. Student 14 19%
Researcher 11 15%
Professor > Associate Professor 4 5%
Other 4 5%
Other 10 14%
Unknown 12 16%
Readers by discipline Count As %
Psychology 14 19%
Neuroscience 12 16%
Medicine and Dentistry 12 16%
Agricultural and Biological Sciences 6 8%
Engineering 3 4%
Other 7 10%
Unknown 19 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2015.
All research outputs
#2,944,760
of 11,331,024 outputs
Outputs from Molecular Autism
#242
of 362 outputs
Outputs of similar age
#66,431
of 227,160 outputs
Outputs of similar age from Molecular Autism
#17
of 23 outputs
Altmetric has tracked 11,331,024 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 362 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.7. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,160 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.