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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Chemoresistance of glioblastoma cancer stem cells - much more complex than expected
|
|---|---|
| Published in |
Molecular Cancer, October 2011
|
| DOI | 10.1186/1476-4598-10-128 |
| Pubmed ID | |
| Authors |
Dagmar Beier, Joerg B Schulz, Christoph P Beier |
| Abstract |
Glioblastomas (GBM) are a paradigm for the investigation of cancer stem cells (CSC) in solid malignancies. The susceptibility of GBM CSC to standard chemotherapeutic drugs is controversial as the existing literature presents conflicting experimental data. Here, we summarize the experimental evidence on the resistance of GBM CSC to alkylating chemotherapeutic agents, with a special focus on temozolomide (TMZ). The data suggests that CSC are neither resistant nor susceptible to chemotherapy per se. Detoxifying proteins such as O6-methylguanine-DNA-methyltransferase (MGMT) confer a strong intrinsic resistance to CSC in all studies. Extrinsic factors may also contribute to the resistance of CSC to TMZ. These may include TMZ concentrations in the brain parenchyma, TMZ dosing schemes, hypoxic microenvironments, niche factors, and the re-acquisition of stem cell properties by non-stem cells. Thus, the interaction of CSC and chemotherapy is more complex than may be expected and it is necessary to consider these factors in order to overcome chemoresistance in the patient. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 293 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| United States | 2 | <1% |
| Netherlands | 2 | <1% |
| Hungary | 1 | <1% |
| Switzerland | 1 | <1% |
| Brazil | 1 | <1% |
| Portugal | 1 | <1% |
| Belgium | 1 | <1% |
| Germany | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 279 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 72 | 25% |
| Student > Master | 45 | 15% |
| Researcher | 39 | 13% |
| Student > Bachelor | 32 | 11% |
| Student > Doctoral Student | 25 | 9% |
| Other | 43 | 15% |
| Unknown | 37 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 92 | 31% |
| Biochemistry, Genetics and Molecular Biology | 57 | 19% |
| Medicine and Dentistry | 54 | 18% |
| Neuroscience | 14 | 5% |
| Chemistry | 12 | 4% |
| Other | 20 | 7% |
| Unknown | 44 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2021.
All research outputs
#5,188,619
of 25,374,917 outputs
Outputs from Molecular Cancer
#423
of 1,918 outputs
Outputs of similar age
#28,552
of 148,450 outputs
Outputs of similar age from Molecular Cancer
#4
of 18 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,918 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 148,450 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.