Title |
Skin CD30+ T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease
|
---|---|
Published in |
Autoimmunity Highlights, August 2013
|
DOI | 10.1007/s13317-013-0054-7 |
Pubmed ID | |
Authors |
Amedeo Amedei, Nicola Pimpinelli, Alessia Grassi, Chiara Della Bella, Elena Niccolai, Simona Brancati, Marisa Benagiano, Sofia D’Elios, Alberto Bosi, Mario M. D’Elios |
Abstract |
To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD. Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD. These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 25% |
Other | 3 | 19% |
Student > Ph. D. Student | 2 | 13% |
Student > Bachelor | 1 | 6% |
Student > Master | 1 | 6% |
Other | 3 | 19% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 31% |
Agricultural and Biological Sciences | 2 | 13% |
Immunology and Microbiology | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Nursing and Health Professions | 1 | 6% |
Other | 2 | 13% |
Unknown | 3 | 19% |