Title |
Current findings for recurring mutations in acute myeloid leukemia
|
---|---|
Published in |
Journal of Hematology & Oncology, September 2011
|
DOI | 10.1186/1756-8722-4-36 |
Pubmed ID | |
Authors |
Shinichiro Takahashi |
Abstract |
The development of acute myeloid leukemia (AML) is a multistep process that requires at least two genetic abnormalities for the development of the disease. The identification of genetic mutations in AML has greatly advanced our understanding of leukemogenesis. Recently, the use of novel technologies, such as massively parallel DNA sequencing or high-resolution single-nucleotide polymorphism arrays, has allowed the identification of several novel recurrent gene mutations in AML. The aim of this review is to summarize the current findings for the identification of these gene mutations (Dnmt, TET2, IDH1/2, NPM1, ASXL1, etc.), most of which are frequently found in cytogenetically normal AML. The cooperative interactions of these molecular aberrations and their interactions with class I/II mutations are presented. The prognostic and predictive significances of these aberrations are also reviewed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Netherlands | 1 | <1% |
United States | 1 | <1% |
India | 1 | <1% |
Unknown | 248 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 21% |
Student > Master | 37 | 15% |
Researcher | 33 | 13% |
Student > Bachelor | 33 | 13% |
Student > Postgraduate | 11 | 4% |
Other | 31 | 12% |
Unknown | 55 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 66 | 26% |
Medicine and Dentistry | 51 | 20% |
Agricultural and Biological Sciences | 46 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
Chemistry | 7 | 3% |
Other | 15 | 6% |
Unknown | 60 | 24% |