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Study of sedative activity of different extracts of Kaempferia galanga in Swiss albino mice

Overview of attention for article published in BMC Complementary Medicine and Therapies, May 2015
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  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

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Title
Study of sedative activity of different extracts of Kaempferia galanga in Swiss albino mice
Published in
BMC Complementary Medicine and Therapies, May 2015
DOI 10.1186/s12906-015-0670-z
Pubmed ID
Authors

Mohammad Shawkat Ali, Pritesh Ranjan Dash, Mahmuda Nasrin

Abstract

Kaempferia galanga is an important medicinal plant and has been traditionally used to help restlessness, stress, anxiety, depression etc. in tropics and subtropics of Asia including Bangladesh, India, China, Japan and Indochina. Literature survey revealed that there are very less reports on neuropharmacological activity of this plant. Therefore, the present study investigated the sedative activity of different extracts of rhizome and leaf of Kaempferia galanga. The sedative activity was evaluated by using thiopental sodium induced sleeping time, hole cross and open field tests in Swiss albino mice at the doses of 100 and 200 mg/kg body weight per oral (p.o). The acetone extract of rhizome (ACR), as well as petroleum ether fraction (PEF), chloroform fraction (CHF), methanol fraction (MEF) and acetone extract of leaf (ACL) were examined for sedative activity. In the sedative activity study, all the extracts exhibited significant (p < 0.05 and p < 0.001) reduction of onset and duration of thiopental sodium induced sleeping time, reduction of locomotor and exploratory activities in the hole cross and open field tests. In thiopental sodium induced sleeping time test, the chloroform extract of rhizome (200 mg/kg) showed maximum 358.55 % effect in duration of loss of righting reflex, whereas the standard drug Diazepam (2 mg/kg) produced 231.42 % effect. In hole cross and open field tests, maximum 95.09 % and 95.58 % suppression of locomotor activity were observed with the acetonic leaf extract (200 mg/kg) whereas suppression of locomotor activity of the standard drug Diazepam were 71.70 % and 70.58 % respectively. The present study indicates that the acetone extracts of rhizome and leaf of Kaempferia galanga including fractions possess central nervous system (CNS) depressant properties which supports its use in traditional medicine. So, the plant may be further investigated to find out for its pharmacological active natural products.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 103 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 13%
Student > Master 12 12%
Researcher 7 7%
Student > Ph. D. Student 6 6%
Lecturer 5 5%
Other 20 19%
Unknown 40 39%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 23 22%
Agricultural and Biological Sciences 9 9%
Biochemistry, Genetics and Molecular Biology 8 8%
Medicine and Dentistry 5 5%
Neuroscience 4 4%
Other 14 14%
Unknown 40 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2022.
All research outputs
#13,140,869
of 23,509,982 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,374
of 3,700 outputs
Outputs of similar age
#118,471
of 268,061 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#22
of 81 outputs
Altmetric has tracked 23,509,982 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,700 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,061 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.