Title |
Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations
|
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Published in |
BMC Biophysics, April 2011
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DOI | 10.1186/2046-1682-4-8 |
Pubmed ID | |
Authors |
Balaji VS Iyer, Martin Kenward, Gaurav Arya |
Abstract |
Eukaryotic genomes possess an elaborate and dynamic higher-order structure within the limiting confines of the cell nucleus. Knowledge of the physical principles and the molecular machinery that govern the 3D organization of this structure and its regulation are key to understanding the relationship between genome structure and function. Elegant microscopy and chromosome conformation capture techniques supported by analysis based on polymer models are important steps in this direction. Here, we review results from these efforts and provide some additional insights that elucidate the relationship between structure and function at different hierarchical levels of genome organization. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 3% |
United Kingdom | 1 | <1% |
Germany | 1 | <1% |
Unknown | 113 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 23 | 19% |
Student > Ph. D. Student | 21 | 18% |
Student > Bachelor | 18 | 15% |
Professor | 10 | 8% |
Student > Master | 8 | 7% |
Other | 17 | 14% |
Unknown | 21 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 39 | 33% |
Biochemistry, Genetics and Molecular Biology | 31 | 26% |
Chemistry | 6 | 5% |
Physics and Astronomy | 6 | 5% |
Chemical Engineering | 3 | 3% |
Other | 8 | 7% |
Unknown | 25 | 21% |