Title |
Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission
|
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Published in |
Malaria Journal, May 2015
|
DOI | 10.1186/s12936-015-0736-x |
Pubmed ID | |
Authors |
Andrew Teo, Wina Hasang, Louise M. Randall, Holger W. Unger, Peter M. Siba, Ivo Mueller, Graham V. Brown, Stephen J. Rogerson |
Abstract |
Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels. Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea. NCT01136850 . |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Unknown | 82 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 16 | 19% |
Student > Ph. D. Student | 11 | 13% |
Researcher | 10 | 12% |
Student > Bachelor | 7 | 8% |
Other | 6 | 7% |
Other | 17 | 20% |
Unknown | 16 | 19% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 30% |
Nursing and Health Professions | 10 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 8% |
Agricultural and Biological Sciences | 5 | 6% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Other | 14 | 17% |
Unknown | 18 | 22% |