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Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission

Overview of attention for article published in Malaria Journal, May 2015
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Title
Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission
Published in
Malaria Journal, May 2015
DOI 10.1186/s12936-015-0736-x
Pubmed ID
Authors

Andrew Teo, Wina Hasang, Louise M. Randall, Holger W. Unger, Peter M. Siba, Ivo Mueller, Graham V. Brown, Stephen J. Rogerson

Abstract

Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels. Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea. NCT01136850 .

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 82 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 19%
Student > Ph. D. Student 11 13%
Researcher 10 12%
Student > Bachelor 7 8%
Other 6 7%
Other 17 20%
Unknown 16 19%
Readers by discipline Count As %
Medicine and Dentistry 25 30%
Nursing and Health Professions 10 12%
Pharmacology, Toxicology and Pharmaceutical Science 7 8%
Agricultural and Biological Sciences 5 6%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 14 17%
Unknown 18 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2015.
All research outputs
#14,685,107
of 22,807,037 outputs
Outputs from Malaria Journal
#4,195
of 5,563 outputs
Outputs of similar age
#145,655
of 266,750 outputs
Outputs of similar age from Malaria Journal
#75
of 109 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,563 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,750 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 109 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.