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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mechanism of regulation of stem cell differentiation by matrix stiffness
|
|---|---|
| Published in |
Stem Cell Research & Therapy, May 2015
|
| DOI | 10.1186/s13287-015-0083-4 |
| Pubmed ID | |
| Authors |
Hongwei Lv, Lisha Li, Meiyu Sun, Yin Zhang, Li Chen, Yue Rong, Yulin Li |
| Abstract |
Stem cell behaviors are regulated by multiple microenvironmental cues. As an external signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate determination, but how this biophysical cue is translated into intracellular signaling remains elusive. Here, we elucidate mechanisms by which stem cells respond to microenvironmental stiffness through the dynamics of the cytoskeletal network, leading to changes in gene expression via biophysical transduction signaling pathways in two-dimensional culture. Furthermore, a putative rapid shift from original mechanosensing to de novo cell-derived matrix sensing in more physiologically relevant three-dimensional culture is pointed out. A comprehensive understanding of stem cell responses to this stimulus is essential for designing biomaterials that mimic the physiological environment and advancing stem cell-based clinical applications for tissue engineering. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 486 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Japan | 2 | <1% |
| Australia | 1 | <1% |
| Portugal | 1 | <1% |
| Colombia | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 477 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 125 | 26% |
| Student > Master | 76 | 16% |
| Student > Bachelor | 56 | 12% |
| Researcher | 51 | 10% |
| Student > Doctoral Student | 23 | 5% |
| Other | 63 | 13% |
| Unknown | 92 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 102 | 21% |
| Engineering | 78 | 16% |
| Agricultural and Biological Sciences | 72 | 15% |
| Medicine and Dentistry | 33 | 7% |
| Materials Science | 28 | 6% |
| Other | 63 | 13% |
| Unknown | 110 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2015.
All research outputs
#17,758,791
of 22,808,725 outputs
Outputs from Stem Cell Research & Therapy
#1,584
of 2,418 outputs
Outputs of similar age
#179,909
of 266,724 outputs
Outputs of similar age from Stem Cell Research & Therapy
#39
of 53 outputs
Altmetric has tracked 22,808,725 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,724 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.