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PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial

Overview of attention for article published in Trials, June 2015
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Title
PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial
Published in
Trials, June 2015
DOI 10.1186/s13063-015-0774-2
Pubmed ID
Authors

Toby Richards, Ben Clevenger, Jane Keidan, Tim Collier, Andrew A. Klein, Stefan D. Anker, John D. Kelly

Abstract

Anaemia is common in patients undergoing major surgery. The current standard of care for patients with low haemoglobin in the peri-operative period is blood transfusion. The presence of preoperative anaemia is associated with an increased likelihood of the patient receiving peri-operative transfusion and worsened outcomes following surgery, more post-operative complications, delayed recovery and greater length of hospital stay. Intravenous iron, if applied in the preoperative setting, may correct anaemia by the time of surgery and reduce the need for blood transfusion and improve outcomes. PREVENTT is a phase III double-blind randomised controlled trial that will compare the use of intravenous ferric carboxymaltose (dose 1000 mg) with placebo 10-42 days before major open abdominal surgery in 500 patients with anaemia (haemoglobin < 120 g/L). The primary outcome measure will be the need for blood transfusion and secondary endpoints will include post-operative recovery, length of hospital stay, health care utilisation and cost analysis. ISRCTN67322816 - registered 9 October 2012. ClinicalTrials.gov identifier: NCT01692418 .

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Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Denmark 1 <1%
Unknown 146 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 24 16%
Researcher 17 11%
Student > Postgraduate 13 9%
Student > Ph. D. Student 13 9%
Other 12 8%
Other 32 22%
Unknown 37 25%
Readers by discipline Count As %
Medicine and Dentistry 66 45%
Nursing and Health Professions 9 6%
Unspecified 6 4%
Agricultural and Biological Sciences 5 3%
Biochemistry, Genetics and Molecular Biology 3 2%
Other 15 10%
Unknown 44 30%