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Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis

Overview of attention for article published in Critical Care, December 2015
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  • Good Attention Score compared to outputs of the same age (74th percentile)

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2 X users
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1 patent
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1 Facebook page

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88 Mendeley
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Title
Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-0972-z
Pubmed ID
Authors

Xiao Wang, Zhong-Yun Li, Ling Zeng, An-Qiang Zhang, Wei Pan, Wei Gu, Jian-Xin Jiang

Abstract

Recently, neutrophil CD64 (nCD64) expression appears to be a promising marker of bacterial infections. The aim of this meta-analysis was to assess the accuracy of nCD64 expression for the diagnosis of sepsis in critically ill adult patients. We systematically searched PubMed, Embase, ISI Web of Knowledge, and the Cochrane Library from inception to May 19, 2014, and reference lists of identified primary studies. Studies were included if they assessed the accuracy of nCD64 expression for sepsis diagnosis in adult patients and provided sufficient information to construct a 2 X 2 contingency table. A total of 8 studies including 1986 patients fulfilled the inclusion criteria for the final analysis. The pooled sensitivity and specificity was 0.76 (95 % confidence interval (CI), 0.73 to 0.78) and 0.85 (95 % CI, 0.82 to 0.87), respectively. The positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 8.15 (95 % CI, 3.82 to 17.36), 0.16 (95 % CI, 0.09 to 0.30), and 60.41 (95 % CI, 15.87 to 229.90), respectively. The area under the SROC of nCD64 expression with Q* value were 0.95 (Q* = 0.89). On the basis of our meta-analysis, nCD64 expression is a helpful marker for early diagnosis of sepsis in critically ill patients. The results of the test should not be used alone to diagnose sepsis, but should be interpreted in combination with medical history, physical examination, and other test results.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 16%
Student > Ph. D. Student 13 15%
Other 8 9%
Researcher 6 7%
Student > Doctoral Student 5 6%
Other 16 18%
Unknown 26 30%
Readers by discipline Count As %
Medicine and Dentistry 32 36%
Biochemistry, Genetics and Molecular Biology 7 8%
Immunology and Microbiology 5 6%
Mathematics 3 3%
Agricultural and Biological Sciences 3 3%
Other 11 13%
Unknown 27 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2022.
All research outputs
#6,930,204
of 25,374,647 outputs
Outputs from Critical Care
#3,867
of 6,554 outputs
Outputs of similar age
#98,491
of 395,421 outputs
Outputs of similar age from Critical Care
#333
of 466 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,421 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 466 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.