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The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif.

Overview of attention for article published in Biology Direct, January 2009
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
1 blog

Citations

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30 Dimensions

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51 Mendeley
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Title
The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif.
Published in
Biology Direct, January 2009
DOI 10.1186/1745-6150-4-2
Pubmed ID
Authors

Kinch LN, Grishin NV

Abstract

Argonaute (Ago) proteins interact with small regulatory RNAs to mediate gene regulatory pathways. A recent report by Kiriakidou et al. 1 describes an MC sequence region identified in Ago2 that displays similarity to the cap-binding motif in translation initiation factor 4E (eIF4E). In a cap-bound eIF4E structure, two important aromatic residues of the motif stack on either side of a 7-methylguanosine 5'-triphosphate (m7Gppp) base. The corresponding Ago2 aromatic residues (F450 and F505) were hypothesized to perform the same cap-binding function. However, the detected similarity between the MC sequence and the eIF4E cap-binding motif was questionable.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
United Kingdom 1 2%
Argentina 1 2%
Spain 1 2%
Japan 1 2%
Greece 1 2%
United States 1 2%
Unknown 44 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 22%
Student > Master 7 14%
Student > Ph. D. Student 6 12%
Professor > Associate Professor 6 12%
Professor 5 10%
Other 10 20%
Unknown 6 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 51%
Biochemistry, Genetics and Molecular Biology 13 25%
Chemistry 3 6%
Neuroscience 2 4%
Materials Science 1 2%
Other 0 0%
Unknown 6 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2009.
All research outputs
#4,332,843
of 17,353,889 outputs
Outputs from Biology Direct
#189
of 597 outputs
Outputs of similar age
#29,491
of 120,263 outputs
Outputs of similar age from Biology Direct
#2
of 10 outputs
Altmetric has tracked 17,353,889 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 597 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,263 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.